Professor, Internal Medicine, UC, Davis School of Medicine
Cardiology
Dr. Anne A. Knowlton, MD
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Dr. Anne A. Knowlton works in the field of Cardiology. She researched medicine at Yale University School of Medicine. Yale University School of Medicine is a top medical college. Yale University School of Medicine is ranked 7 in research and 57 in primary care medicine Anne Knowlton is also published. She has 87 publications published. The lastest publication: "Differential expression of heat shock proteins in normal and failing human hearts.'
Publications
- TLR4 mutation and HSP60-induced cell death in adult mouse cardiac myocytes.
- Regulation of Gene Transcription by Voltage-Gated L-Type Calcium Channel, Cav1.3.
- Mitochondrial dynamic changes in health and genetic Diseases.
- Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel.
- Heart failure and mitochondrial dysfunction: the role of mitochondrial fission/fusion abnormalities and new therapeutic strategies.
- Mitochondrial proteome remodeling in ischemic Heart failure.
- Innate immunity and cardiomyocytes in ischemic heart Disease.
- Cardiac Myocyte Z-line Calmodulin is Mainly RyR2-Bound and Reduction is Arrhythmogenic and Occurs in Heart Failure.
- Training the translational research teams of the future: UC Davis-HHMI Integrating Medicine into Basic Science program.
- Cardiac Myocyte Exosomes: Stability, HSP60 and Proteomics.
- OPA1 mutation and late-onset Cardiomyopathy: mitochondrial dysfunction and mtDNA instability.
- IRF-1 and miRNA126 Modulate VCAM-1 Expression in Response to a High Fat Meal.
- Mitochondrial dynamics in Heart failure.
- Rapid Activation of Nuclear Factor κB by 17β-Estradiol and Selective Estrogen Receptor Modulators: Pathways Mediating Cellular Protection.
- Regulating a uniter: control of mitofusin 2 expression.
- Estrogen and the cardiovascular system.
- Tocotrienols confer resistance to ischemia in hypercholesterolemic Hearts: insight with genomics.
- Impact of Aging vs. Estrogen Loss on Cardiac Gene Expression: Estrogen Replacement and Inflammation.
- The heat shock paradox and cardiac myocytes: role of heat shock factor.
- 17β-Estradiol, aging, inflammation, and the stress response in the female Heart.
- CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1.
- Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels.
- Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B).
- Extracellular heat shock protein 60, cardiac myocytes, and apoptosis.
- Effects of dietary decosahexaenoic acid (DHA) on eNOS in human Coronary artery endothelial cells.
- Estrogen, NFkappaB, and the heat shock response.
- Effect of ovariectomy on cardiac gene expression: inflammation and changes in SOCS gene expression.
- Triglyceride-rich lipoproteins prime Aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha.
- Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2.
- Inflammation and ischemia: macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes.
- Glutathione S-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer.
- Aging, Estrogen Loss and Epoxyeicosatrienoic Acids (EETs).
- Heme-oxygenase-1: versatile sentinel against injury.
- Randomized phase II clinical trial of adriamycin, methotrexate, and actinomycin-D in advanced measurable pancreatic carcinoma: a Gastrointestinal Tumor Study Group Rep...
- Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorour...
- Blocking the endogenous increase in HSP 72 increases susceptibility to hypoxia and reoxygenation in isolated adult feline cardiocytes.
- Olfactory neuroblastoma. Observations on seven patients treated with radiation therapy and review of the literature.
- Current concepts in transcription, translation, and the regulation of gene expression. A primer for the clinician.
- Complications of inappropriate use of spironolactone in Heart failure: when an old medicine spirals out of new guidelines.
- Life, death, the unfolded protein response and apoptosis.
- Long term survivors with small cell carcinoma of the lung.
- Congestive heart failure and outpatient risk of venous thromboembolism: a retrospective, case-control study.
- Expression of heat shock proteins in turtle and mammal Hearts: relationship to anoxia tolerance.
- A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat shock protein 70 in the isolated, erythrocyte-perfused rabbit Heart.
- Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia.
- Mutation of amino acids 246-251 alters nuclear accumulation of human heat shock protein (HSP) 72 with stress, but does not reduce viability.
- Presence of heat shock protein 72 in cardiomyocytes after heat stress.
- Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in c...
- Rabbit Heart fatty acid-binding protein. Isolation, characterization, and application of a monoclonal antibody.
- Phosphorylation at tyrosine-524 influences nuclear accumulation of HSP72 with heat stress.
- NFkappaB, heat shock proteins, HSF-1, and inflammation.
- Hsp72 expression enhances survival in adenosine triphosphate-depleted renal epithelial cells.
- Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells.
- Estrogen and cardiovascular Disease: aging and estrogen loss at the heart of the matter?
- Aging, ischemia and the Heart.
- Effect of mutation of amino acids 246-251 (KRKHKK) in HSP72 on protein synthesis and recovery from hypoxic injury.
- Toll-like receptor 4 deficiency: smaller infarcts, but no gain in function.
- Heat-shock protein 60 and cardiovascular Disease: a paradoxical role.
- Heat-shock proteins, stress, and the Heart.
- Activation of heat-shock factor by stretch-activated channels in rat Hearts.
- Activation of the heat shock response: relationship to energy metabolites. A (31)P NMR study in rat Hearts.
- The role of heat shock proteins in the Heart.
- Mutation of amino acids 566-572 (KKKVLDK) inhibits nuclear accumulation of heat shock protein 72 after heat shock.
- Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes.
- Activation of HSF and selective increase in heat-shock proteins by acute dexamethasone treatment.
- Mitochondria and Heart failure: new insights into an energetic problem.
- Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the Heart.
- HSP60, Bax, and cardiac apoptosis.
- Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia.
- Tumor necrosis factor-alpha confers resistance to hypoxic injury in the adult mammalian cardiac myocyte.
- Pathologic stage I and II Hodgkin's Disease. Long-term results at three Connecticut hospitals.
- HSP60, Bax, apoptosis and the Heart.
- Mitochondrial OPA1, apoptosis, and Heart failure.
- HSP60 in Heart failure: abnormal distribution and role in cardiac myocyte apoptosis.
- Differential expression of heat shock proteins in normal and failing human Hearts.
- Gender differences in the expression of heat shock proteins: the effect of estrogen.
- Cytosolic heat shock protein 60, hypoxia, and apoptosis.
- Estrogen and regulation of heat shock protein expression in female cardiomyocytes: cross-talk with NF kappa B signaling.
- Cytosolic heat shock protein 60, apoptosis, and myocardial injury.
- Estrogen, aging and the cardiovascular system.
- HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway.
- Regulation of prostaglandin A1-induced heat shock protein expression in isolated cardiomyocytes.
- Regulation of heat shock protein 60 and 72 expression in the failing Heart.
- Estrogen, heat shock proteins, and NFkappaB in human vascular endothelium.
- Role of aging versus the loss of estrogens in the reduction in vascular function in female rats.
- Stage I and II subdiaphragmatic Hodgkin's Disease.
Schools
Yale University
Boston City Hospital
Boston University Med Center
Conditions Treated
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomyopathy
- Congestive Heart Failure
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Doctors Specialties
- Cardiology
Accepted Insurances
Education
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Boston University Medical Center -
Yale University School of Medicine
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