Associate Professor, Pediatrics, University of Wisconsin Medical School

Allergy & Immunology

Doctor Christine M. Seroogy, MD works in the field of Allergy & Immunology. She went to medical school at University of Minnesota Medical School. University of Minnesota Medical School is ranked 40 in research and 10 in primary care medicine She over the years received 1 awards: "Fellow (FAAAAI)". Christine Seroogy has written publications. She has 41 publications published with PubMed. The lastest publication is: 'Local delivery of cytokines by retrovirally transduced antigen-specific TCR+ hybridoma cells in experimental autoimmune encephalomyelitis.'

Publications

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• Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.
• The F-bar protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages.
• Novel Mutation in TP63 Associated With Ectrodactyly Ectodermal Dysplasia and Clefting Syndrome and T Cell Lymphopenia.
• Human eosinophils release IL-1ß and increase expression of IL-17A in activated CD4(+) T lymphocytes.
• An optimized multi-parameter flow cytometry protocol for human T regulatory cell analysis on fresh and viably frozen cells, correlation with epigenetic analysis, and c...
• Newborn Screening for Severe Combined ImmunoDeficiency; The Wisconsin Experience (2008-2011).
• Suppression of T-Cell Expansion by Melanoma is Exerted on Resting Cells.
• Expression patterns of atopic eczema and respiratory illnesses in a high-risk birth cohort.
• Atypical presentation of IL-12 receptor beta1 Deficiency with pneumococcal sepsis and disseminated nontuberculous mycobacterial infection in a 19-month-old girl born t...
• Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells.
• Transfer of tolerance to collagen type V suppresses T-helper-cell-17 lymphocyte-mediated acute lung transplant rejection.
• Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions.
• Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin.
• Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy.
• Adolescent presentation of x-linked lymphoproliferative disease.
• Association between CD4(+)CD25(high) T cells and atopy in children.
• GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype.
• Dendritic cells amplify T cell-mediated Immune responses in the central nervous system.
• The role of T regulatory cells in asthma.
• The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.
• T-cell anergy: from phenotype to genotype and back.
• Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4.
• CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation.
• Sustained expression of GRAIL during hematopoiesis results in dysregulated differentiation.
• Recurrent superantigen exposure in vivo leads to highly suppressive CD4+CD25+ and CD4+CD25- T cells with anergic and suppressive genetic signatures.
• Daily subcutaneous injections of peptide induce CD4+ CD25+ T regulatory cells.
• Preservation of self: an overview of E3 ubiquitin ligases and T cell tolerance.
• Malignant B cell CD5 membrane phenotype and B cell colony growth in vivo and in vitro in patients with B-chronic lymphocytic leukemia: analysis with clinical parameters.
• A gene therapy approach to treatment of autoImmune disease.
• Local delivery of cytokines by retrovirally transduced antigen-specific TCR+ hybridoma cells in experimental autoImmune encephalomyelitis.
• Cytokine profile of a long-term pediatric HIV survivor with hyper-IgE syndrome and a normal CD4 T-cell count.
• The application of gene therapy in autoImmune diseases.
• Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoImmune disease.
• Gene therapy for autoImmune disease.
• Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis.
• Application of gene therapy in autoImmune disease.
• GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells.
• Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor.
• Two isoforms of otubain 1 regulate T cell anergy via GRAIL.
• Cbl-b regulates antigen-induced TCR down-regulation and IFN-gamma production by effector CD8 T cells without affecting functional avidity.

Schools

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• University of Mn Med Sch

Conditions Treated

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• Common Variable Immune Deficiency (CVID)
• Hypogammaglobulinemia

Doctors Specialties

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• Pediatrics
• Allergy
• Immunology

Accepted Insurances

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Awards

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• Fellow (FAAAAI)

Education

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• Stanford University
• Boston Children's Hospital
• University of California San Diego
• University of Minnesota Medical School

Hospital

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• University of Wisconsin Hospital and Clinics

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