Physician

Family Medicine

Dr. David B. Heal, MD

David Heal practices Family Medicine. David Heal is a published doctor and has 101 publications published. The lastest was: 'A comparison of the effects on central 5-HT function of sibutramine hydrochloride and other weight-modifying agents.'

Publications

Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male Wistar rats independently of hypothalamic neuropeptide Y.
Comparison of the effects of bupropion and nicotine on locomotor activation and dopamine release in vivo.
Obesity drug development - CBI''s 2nd Annual Summit.
Methylphenidate and its isomers: their role in the treatment of attention-deficit hyperactivity disorder using a transdermal delivery system.
Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats.
KTX 0101: a potential metabolic approach to cytoprotection in major surgery and neurological disorders.
Pharmacological characterisation of the thermogenic effect of bupropion.
5-HT has contrasting effects in the frontal cortex, but not the hypothalamus, on changes in noradrenaline efflux induced by the monoamine releasing-agent, d-amphetamin...
Acute cardiovascular effects of sibutramine in conscious rats.
Noradrenaline clearance differs in the frontal cortex and hypothalamus: a dual-probe microdialysis study in freely-moving rats.
Differences in the mechanisms that increase noradrenaline efflux after administration of d-amphetamine: a dual-probe microdialysis study in rat frontal cortex and hypo...
Comparison of the thermogenic and hypophagic effects of sibutramine''s metabolite 2 and other monoamine reuptake inhibitors.
Effects on serotonin in rat hypothalamus of D-fenfluramine, aminorex, phentermine and fluoxetine.
ADHD: Current and Future Therapeutics.
The 5-HT6 receptor as a target for developing novel antiobesity drugs.
Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders.
SOME CANNABINOID RECEPTOR LIGANDS AND THEIR DISTOMERS ARE DIRECT ACTING OPENERS OF SUR1 K-ATP CHANNELS.
Antidepressant treatments, including electroconvulsive shock and the putative antidepressant sibutramine hydrochloride, do not alter [3H]-prazosin binding to rat corti...
The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety.
New perspectives from microdialysis studies in freely-moving, spontaneously hypertensive rats on the pharmacology of drugs for the treatment of ADHD.
Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders.
Determination of body composition in conscious adult female Wistar utilising total body electrical conductivity.
Monoamine oxidase inhibition is unlikely to be relevant to the risks associated with phentermine and fenfluramine: a comparison with their abilities to evoke monoamine...
Additive effects on rat brain 5HT release of combining phentermine with dexfenfluramine.
BTS 72664-- a novel CNS drug with potential anticonvulsant, neuroprotective, and antimigraine properties.
Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine.
Comparison of the effects of sibutramine and other weight-modifying drugs on extracellular dopamine in the nucleus accumbens of freely moving rats.
Sibutramine does not decrease the number of 5-HT re-uptake sites in rat brain and, like fluoxetine, protects against the deficits produced by dexfenfluramine.
A comparison of the acute effects of zotepine and other antipsychotics on rat cortical dopamine release, in vivo.
Modulation of sibutramine-induced increases in extracellular noradrenaline concentration in rat frontal cortex and hypothalamus by alpha2-adrenoceptors.
Comparison of changes in the extracellular concentration of noradrenaline in rat frontal cortex induced by sibutramine or d-amphetamine: modulation by alpha2-adrenocep...
The effects of the peptide-coupling agent, EEDQ, on 5-HT2A receptor binding and function in rat frontal cortex.
Thermogenic effects of sibutramine and its metabolites.
A comparison of the effects on central 5-HT function of sibutramine hydrochloride and other weight-modifying agents.
Elevation of extracellular cortical noradrenaline may contribute to the antidepressant activity of zotepine: an in vivo microdialysis study in freely moving rats.
Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine.
GABA-evoked depolarisations in the rat cortical wedge: involvement of GABAA receptors and HCO3- ions.
The anxiogenic agents, yohimbine and FG 7142, disrupt the noradrenergic response to novelty.
Weak blockade of AMPA receptor-mediated depolarisations in the rat cortical wedge by phenytoin but not lamotrigine or carbamazepine.
In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor.
Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat.
Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat.
8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation.
Zotepine: preclinical tests predict antipsychotic efficacy and an atypical profile.
D1 receptor binding in rat striatum: modification by various D1 and D2 antagonists, but not by sibutramine hydrochloride, antidepressants or treatments which enhance c...
[3H]nisoxetine--a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressan...
Mediation of the antidepressant-like effect of 8-OH-DPAT in mice by postsynaptic 5-HT1A receptors.
[3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments.
Evidence that RU 24969-induced locomotor activity in C57/B1/6 mice is specifically mediated by the 5-HT1B receptor.
Reserpinization severs the cooperative but not the oppositional interaction between D1 and D2 receptors.
Common profile of D1 receptor antagonists and atypical antipsychotic drugs revealed by analysis of dopamine turnover.
Evidence for altered alpha 2-adrenoceptor function following isolation-rearing in the rat.
Dopamine D2 receptors: a potential pharmacological target for nomifensine and tranylcypromine but not other antidepressant treatments.
Long-lasting effects of an acute stress on the neurochemistry and function of 5-hydroxytryptaminergic neurones in the mouse brain.
Mediation of mydriasis in conscious rats by central postsynaptic alpha 2-adrenoceptors.
Quantification of presynaptic alpha 2-adrenoceptors in rat brain after short-term DSP-4 lesioning.
Receptor binding and functional evidence suggest that postsynaptic alpha 2-adrenoceptors in rat brain are of the alpha 2D subtype.
Repeated electroconvulsive shock attenuates clonidine-induced hypoactivity in rodents.
Hypophysectomy does not prevent the enhanced monoamine-mediated behavioural responses following repeated electroconvulsive shocks.
Repeated administration of triiodothyronine (T3) to rats enhances nigrostriatal and mesolimbic dopaminergic behavioural responses.
Repeated administration of subconvulsant doses of GABA antagonist drugs. II. Effect on monoamine-mediated behaviour.
Behavioural effects of central and peripheral injection of various analogues and metabolites of thyrotropin releasing hormone (TRH).
Antidepressant treatments: effects in rodents on dose-response curves of 5-hydroxytryptamine- and dopamine-mediated behaviours and 5-HT2 receptor number in frontal cor...
Effects of thyroid status on presynaptic alpha 2-adrenoceptor function and beta-adrenoceptor binding in the rat brain.
The effects of acute and repeated administration of various antidepressant drugs on clonidine-induced hypoactivity in mice and rats.
Hypophysectomy alters both 5-hydroxytryptamine- and alpha 2-adrenoceptor-mediated behavioural changes in the rat.
The effects of iron deficiency on brain biogenic monoamine biochemistry and function in rats.
Studies on the mechanisms by which clenbuterol, a beta-adrenoceptor agonist, enhances 5-HT-mediated behaviour and increases metabolism of 5-HT in the brain of the rat.
Phenylephrine-induced activity in mice as a model of central alpha 1-adrenoceptor function. Effects of acute and repeated administration of antidepressant drugs and el...
beta-Adrenoceptor agonists enhance 5-hydroxytryptamine-mediated behavioural responses.
Inhibition of apomorphine-, bromocriptine- and lergotrile-induced circling behaviour in rats by subsequent haloperidol administration.
Effects of thyroid status on clonidine-induced hypoactivity responses in the developing rat.
Proceedings: Inhibition of adenyl cyclase by a bacterial exotoxin.
Intracerebroventricular administration of 5,7-dihydroxytryptamine to mice increases both head-twitch response and the number of cortical 5-HT2 receptors.
DSP-4 lesioning prevents the enhancement of dopamine and 5-hydroxytryptamine mediated behavioural changes by repeated electroconvulsive shock.
Determination of 3-methoxytyramine in rat brain by HPLC with electrochemical detection and its correlation with dopamine function after administration of a monoamine o...
In mice repeated administration of electroconvulsive shock or desmethylimipramine produces rapid alterations in 5-HT2-mediated head-twitch responses and cortical 5-HT2...
The effects of single and repeated electroconvulsive shock administration on the release of 5-hydroxytryptamine and noradrenaline from cortical slices of rat brain.
Repeated electroconvulsive shock prevents increased neocortical beta 1-adrenoceptor binding after DSP-4 treatment in rats.
The effects of electroconvulsive therapy and antidepressant drugs on monoamine receptors in rodent brain--similarities and differences.
The influence of central noradrenergic function on 5-HT2-mediated head-twitch responses in mice: possible implications for the actions of antidepressant drugs.
Studies on rat brain catecholamine synthesis and beta-adrenoceptor number following administration of electroconvulsive shock, desipramine and clenbuterol.
The effects of acute and repeated administration of T3 to mice on 5-HT1 and 5-HT2 function in the brain and its influence on the actions of repeated electroconvulsive ...
A study of the possible influence of central 5-HT function on clonidine-induced hypoactivity responses in mice.
The pharmacology of the behavioural and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).
Effect of chronic treatment with 5-HT1 agonist (8-OH-DPAT and RU 24969) and antagonist (isapirone) drugs on the behavioural responses of mice to 5-HT1 and 5-HT2 agonists.
The beta 2-adrenoceptor agonists clenbuterol and salbutamol enhance the hypothermic action of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice by a central m...
Behavioural and biochemical evidence for the release of noradrenaline in mouse brain by TRH and some of its biologically stable analogues.
The influence of injection of oestradiol to female rats on changes in alpha 2- and beta-adrenoceptor function induced by repeated administration of desipramine or elec...
5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in the mouse cortex has pharmacological characteristics compatible with mediation via 5-HT2 receptors b...
Hypothermia induced by baclofen, a possible index of GABAB receptor function in mice, is enhanced by antidepressant drugs and ECS.
The influence of L-triiodothyronine (T3) on the effects of repeated administration of desipramine or electroconvulsive shock on alpha 2- and beta-adrenoceptor function...
The effects of desipramine (DMI) and electroconvulsive shock (ECS) on the function of the hypothalamo-pituitary-thyroid axis in the rat.
Chronic lithium treatment enhances inositol polyphosphate formation in mouse brain in vivo.
Measurement of 3-methoxytyramine by in vivo voltammetry: evidence for differences in central dopamine function in BALB/c and CBA mice.
Clonidine produces mydriasis in conscious mice by activating central alpha 2-adrenoceptors.
Clonidine-induced hypoactivity and mydriasis in mice are respectively mediated via pre- and postsynaptic alpha 2-adrenoceptors in the brain.
Antidepressant treatments, including sibutramine hydrochloride and electroconvulsive shock, decrease beta 1- but not beta 2-adrenoceptors in rat cortex.
Sex-related differences in central adrenergic function and responsiveness to repeated administration of desipramine or electroconvulsive shock.
Measurement of 3-methoxy-4-hydroxyphenylglycol (MHPG) in mouse brain by h.p.l.c. with electrochemical detection, as an index of noradrenaline utilisation and presynapt...

Doctors Specialties

Family Medicine

Accepted Insurances

Helpful Reviews

Give Anonymous Review

Similar Doctors

	Dr. Pedro A. Souffront Pujol Sr., MD
	Dr. Hector E. Sanchez, MD
	Dr. Marie L. Rivera Polanco, MD
	Dr. Denia E. Gonzalez Aybar, MD
	Dr. Carlos M. Heredia, MD This Doctor is OpenDoctor Recommended.
	Dr. Ivan Torres Silva, MD
	Dr. Rafael A. Rodriguez Nazario, MD
	Dr. Eduardo F. Umpierre Vela, MD This Doctor is OpenDoctor Recommended.