Associate Professor of Orthopedic Surgery, Massachusetts General Hospital
Orthopaedic Surgery
Dr. Francis J. Hornicek Jr., MD
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Francis Hornicek works in the field of Orthopaedic Surgery. He studied medicine at University of Pittsburgh School of Medicine. He over the years received 4 awards: "America's Top Doctors", "Boston Magazine", "America's Top Doctors for Cancer" and "Super Doctor". Doctor Francis J. Hornicek Jr., MD is also published. He has 101 publications published. The lastest publication: "Targeting protein kinases to reverse multidrug resistance in sarcoma.' He accepts Medicare payments and is listed with Medicare.gov.
Publications
- Sacral Insufficiency Fractures are Common After High-dose Radiation for Sacral Chordomas Treated With or Without Surgery.
- How Does the Level of Sacral Resection for Primary Malignant Bone Tumors Affect Physical and Mental Health, Pain, Mobility, Incontinence, and Sexual Function?
- NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function.
- Targeting protein kinases to reverse multidrug resistance in sarcoma.
- p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines.
- Complications after surgery for metastatic humeral lesions.
- Near-infrared light activated delivery platform for cancer therapy.
- Chordoma: an update on the pathophysiology and molecular mechanisms.
- Validation of the Spine Oncology Study Group Outcomes Questionnaire to assess quality of life in patients with metastatic spine Disease.
- NSC23925 prevents the emergence of multidrug resistance in ovarian cancer in vitro and in vivo.
- Cytomorphologic features that distinguish schwannoma from other low-grade spindle cell lesions.
- Targeted cancer therapy; nanotechnology approaches for overcoming drug resistance.
- Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system.
- Are Allogeneic Blood Transfusions Associated With Decreased Survival After Surgery for Long-bone Metastatic Fractures?
- Phase 1 study of oral abexinostat, a histone deacetylase inhibitor, in combination with doxorubicin in patients with metastatic sarcoma.
- Role of post-operative radiation boost for soft tissue sarcomas with positive margins following pre-operative radiation and surgery.
- Prognostic significance of treatment-induced pathologic necrosis in extremity and truncal soft tissue sarcoma after neoadjuvant chemoradiotherapy.
- Cluster of Differentiation 44 Targeted Hyaluronic Acid Based Nanoparticles for MDR1 siRNA Delivery to Overcome Drug Resistance in Ovarian Cancer.
- [18F]-Fluoromisonidazole Positron Emission Tomography/Computed Tomography Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine.
- What's New in Primary Bone Tumors.
- EWS-FLI1Â Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma.
- Outcome of operative treatment of metastatic Fractures of the humerus: a systematic review of twenty three clinical studies.
- Classification of failure of limb salvage after reconstructive surgery for bone tumours : a modified system including biological and expandable reconstructions.
- What Are the Functional Results and Complications From Allograft Reconstruction After Partial Hemipelvectomy of the Pubis?
- Use of Bisphosphonates in Orthopedic Surgery: Pearls and Pitfalls.
- Primary Sclerosing Epithelioid Fibrosarcoma of Bone: Analysis of a Series.
- Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925.
- MicroRNA-1 (miR-1) inhibits chordoma cell migration and invasion by targeting slug.
- Non-neoplastic Soft Tissue Masses That Mimic Sarcoma.
- Programmed Cell Death Ligand 1 Expression in Osteosarcoma.
- Prognostic value of myogenic differentiation in undifferentiated pleomorphic sarcomas of soft tissue.
- Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma.
- Surgical site infection in orthopaedic oncology.
- Outcome After Reconstruction of the Proximal Humerus for Tumor Resection: A Systematic Review.
- What's New in Primary Malignant Musculoskeletal Tumors.
- MRI surveillance following treatment of extremity soft tissue sarcoma.
- BRAF mutation in 'sarcomas': a possible method to detect de-differentiated melanomas.
- Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells.
- Primary Myoepithelioma of Bone: A Report of 8 Cases.
- Definitive High Dose Photon/Proton Radiotherapy for Unresected Mobile Spine and Sacral Chordomas.
- Molecular Distinction of Chondrosarcoma From Chondroblastic Osteosarcoma Through IDH1/2 Mutations.
- Targeting hedgehog-GLI-2 pathway in osteosarcoma.
- Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: a pilot study.
- The use of radiation therapy in the management of selected patients with atypical lipomas.
- Role of resection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis type 1.
- Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor.
- Do histologic criteria predict biologic behavior of giant cell lesions?
- Neoadjuvant chemoradiotherapy for patients with high-risk extremity and truncal sarcomas: a 10-year single institution retrospective study.
- Desmoid tumor: analysis of prognostic factors and outcomes in a surgical series.
- Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
- Prognostic factors and outcomes of patients with myxofibrosarcoma.
- Systematic Kinome shRNA Screening Identifies CDK11 (PITSLRE) Kinase Expression is Critical for Osteosarcoma Cell Growth and Proliferation.
- High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes.
- Establishment and characterization of a novel chordoma cell line: CH22.
- Synthesis and Evaluation of (2-(4-Methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol (NSC23925) Isomers To Reverse Multidrug Resistance in Cancer.
- Long-term follow-up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas.
- Chondrosarcoma of the Mobile Spine: A Review of 21 Cases Treated at a Single Center.
- MicroRNA-199a-3p is Down Regulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration.
- Extended dermal apposition: a simple technique for the closure of irradiated perineal and sacral wounds.
- Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma.
- ROCK1 as a potential therapeutic target in osteosarcoma.
- Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review.
- Nanoparticles: a promising modality in the treatment of sarcomas.
- Recurrent chromosomal copy number alterations in sporadic chordomas.
- Management of acral myxoinflammatory fibroblastic sarcoma.
- Proteomic profiling of chordoma.
- Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.
- Phase II Study of Neoadjuvant Bevacizumab and Radiotherapy for Resectable Soft Tissue Sarcomas.
- Extra-abdominal desmoid tumors: a report of 234 cases.
- Low-Dose Neoadjuvant External Beam Radiation Therapy for Soft Tissue Sarcoma.
- Blockage of Stat3 with CDDO-Me inhibits tumor cell growth in chordoma.
- Osteosarcoma of the Spine: experience in 26 patients treated at the Massachusetts General Hospital.
- Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor ...
- An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control.
- Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression.
- Epithelioid sarcoma with heterotopic bone: a morphologic review of 4 cases.
- Characterization and analysis of human chordoma cell lines.
- Monostotic fibrous dysplasia of the Spine: a report of seven cases.
- Maxillofacial and axial/appendicular giant cell lesions: unique tumors or variants of the same Disease?--A comparison of phenotypic, clinical, and radiographic charact...
- Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma.
- A novel target for treatment of chordoma: signal transducers and activators of transcription 3.
- Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteos...
- Phase II study of high-dose photon/proton radiotherapy in the management of Spine sarcomas.
- Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas.
- Orthopaedic . radiology . pathology conference: Chronic multifocal chest and leg Pain in a 34-year-old woman.
- Treatment of metastatic carcinoma to the hip with CT-guided percutaneous acetabuloplasty: report of four cases.
- Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas.
- Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression.
- ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines.
- Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.
- NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance.
- Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the b...
- Latissimus dorsi flap closure of the irradiated clavicular wound.
- Unicameral bone Cyst: a retrospective study of three surgical treatments.
- Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer.
- The vertical and extended rectus abdominis myocutaneous flap for irradiated thigh and groin defects.
- Complications and risk factors for failure of rotationplasty: review of 25 patients.
- Knee mass from severe metallosis after failure of a metal-Backed patellar component total knee arthroplasty.
- Osteoarticular and total Elbow allograft reconstruction with severe bone loss.
- RE: local control in nonmetastatic Pelvic Ewing's sarcoma patients: Outcome and analysis, by Donati, D, et al.
Schools
Univ Of Pittsburgh Sch Of Med
University Of MiamiJackson Mem Hospital
HarvardMass General Hospital
Procedures Preformed
- All Shoulder or Elbow Replacement Procedures
- Dressing and-or Debridement of Wound, Infection, or Burn (Background: yellow;'>incl. Negative Pressure Wound Therapy)
- Dural Repair or Other Spinal Spinal Cord Repair
- Excision of Femur or Knee
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Conditions Treated
- Ankle Sprain and Achilles Tendon Sprain or Rupture
- Anterior Cruciate Ligament (ACL) or Posterior Cruciate Ligament (PCL) Tear
- Arm Background: yellow;'>Background: yellow;'>Background: yellow;'>Fracture (Background: yellow;'>incl. Elbow and Shoulder)
- Ataxia
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Doctors Specialties
- Orthopedic Surgery
- Orthopaedic Surgery
Accepted Insurances
Awards
- America's Top Doctors
- Boston Magazine
- America's Top Doctors for Cancer
- Super Doctor
Education
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Jackson Memorial Hospital - Jackson Health System -
University of Pittsburgh School of Medicine
Hospital
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Massachusetts General Hospital
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