Professor, Internal Medicine, Mayo Medical School
Cardiology
Dr. Frank V. Brozovich, MD
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Frank Brozovich is an expert in the field of Cardiology. He researched medicine at University of Washington School of Medicine. Frank Brozovich is a published MD. He published 58 publications, including: 'Massive pericardial hematoma simulating constrictive pericarditis: a complication of radiofrequency catheter ablation.' He is registered with Medicare and accepts Medicare payments.
Publications
- Cardiac fibrosis in end-stage human Heart failure and the cardiac natriuretic peptide guanylyl cyclase system: regulation and therapeutic implications.
- Differential phosphorylation of LZ+/LZ- MYPT1 isoforms regulates MLC phosphatase activity.
- The role of Pulmonary vascular contractile protein expression in Pulmonary arterial hypertension.
- Transgenic overexpression of ribonucleotide reductase improves cardiac performance.
- Sildenafil and B-type natriuretic peptide Acutely phosphorylate titin and improve diastolic distensibility in vivo.
- MYPT1 isoforms are differentially phosphorylated by protein kinase G.
- Nonmuscle myosin is regulated during smooth muscle contraction.
- Losartan decreases p42/44 MAPK signaling and preserves LZ+ MYPT1 expression.
- MYPT1 mutants demonstrate the importance of aa 888-928 for the interaction with PKGIalpha.
- Images in cardiovascular medicine. Case of anomalous right superior vena cava.
- Vascular reactivity in Heart failure: role of myosin light chain phosphatase.
- Unzipping the role of myosin light chain phosphatase in smooth muscle cell relaxation.
- Rho signaling: agonist stimulation and depolarization come together.
- Creatine phosphate consumption and the actomyosin crossbridge cycle in cardiac muscles.
- Force maintenance in smooth muscle: analysis using sinusoidal perturbations.
- Troponin T isoforms modulate calcium dependence of the kinetics of the cross-bridge cycle: studies using a transgenic mouse line.
- Myosin light chain phosphatase: it gets around.
- Agonist-induced force enhancement: the role of isoforms and phosphorylation of the myosin-targeting subunit of myosin light chain phosphatase.
- The Emperor's New Clothes: PDE5 and the Heart.
- Stepwise shortening: evidence and implications.
- Effect of angiotensin converting enzyme inhibition on the incidence of restenosis after percutaneous transluminal Coronary angioplasty.
- Muscle force and stiffness during activation and relaxation. Implications for the actomyosin ATPase.
- Mechanical changes after histamine activation of intact single vascular smooth muscle cells.
- Agonist activation modulates cross-bridge states in single vascular smooth muscle cells.
- Measurements of intracellular calcium concentration in mammalian vascular smooth muscle cells during agonist-induced contractions.
- Stimulus-specific changes in mechanical properties of vascular smooth muscle.
- Thin filament regulation of force activation is not essential in single vascular smooth muscle cells.
- Massive Pericardial hematoma simulating constrictive pericarditis: a complication of radiofrequency catheter ablation.
- Regulation of force in skinned, single cells of ferret Aortic smooth muscle.
- The frequency response of smooth muscle stiffness during Ca2+-activated contraction.
- PKC regulates agonist-induced force enhancement in single alpha-toxin-permeabilized vascular smooth muscle cells.
- Mechanical strain increases velocity and extent of shortening in cultured airway smooth muscle cells.
- Enhancement of smooth muscle contraction with protein phosphatase inhibitor 1: activation of inhibitor 1 by cGMP-dependent protein kinase.
- Protein kinase C increases force and slows relaxation in smooth muscle: evidence for regulation of the myosin light chain phosphatase.
- Myosin-based cortical tension in Dictyostelium resolved into heavy and light chain-regulated components.
- The smooth muscle cross-bridge cycle studied using sinusoidal length perturbations.
- Selected contribution: mechanical strain increases force production and calcium sensitivity in cultured airway smooth muscle cells.
- Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation.
- Endothelin-1 alters the contractile phenotype of cultured embryonic smooth muscle cells.
- Forced expression of essential myosin light chain isoforms demonstrates their role in smooth muscle force production.
- Fast skeletal muscle troponin T increases the cooperativity of transgenic mouse cardiac muscle contraction.
- Determinants of the contractile properties in the embryonic chicken gizzard and aorta.
- The maximal velocity of vascular smooth muscle shortening is independent of the expression of calponin.
- Regulation of force in vascular smooth muscle.
- The smooth muscle myosin seven amino acid heavy chain insert''s kinetic role in the crossbridge cycle for mouse bladder.
- The kinetic properties of smooth muscle: how a little extra weight makes myosin faster.
- Captopril prevents myosin light chain phosphatase isoform switching to preserve normal cGMP-mediated vasodilatation.
- Nonmuscle myosin, force maintenance, and the tonic contractile phenotype in smooth muscle.
- Intrafamilial variability of noncompaction of the ventricular myocardium.
- PHI-1 induced enhancement of myosin phosphorylation in chicken smooth muscle.
- Myosin heavy chain isoform expression regulates shortening velocity in smooth muscle: studies using an SMB KO mouse line.
- The potential role of MLC phosphatase and MAPK signalling in the pathogenesis of vascular dysfunction in Heart failure.
- Gene expression profiles of vascular smooth muscle show differential expression of mitogen-activated protein kinase pathways during captopril therapy of Heart failure.
- Regulation of the smooth muscle contractile phenotype by nonmuscle myosin.
- PHI-1 interacts with the catalytic subunit of myosin light chain phosphatase to produce a Ca(2+) independent increase in MLC(20) phosphorylation and force in avian smo...
- Effects of h1-calponin ablation on the contractile properties of bladder versus vascular smooth muscle in mice lacking SM-B myosin.
- A dynamic approach reveals non-muscle myosin influences the overall smooth muscle cross-bridge cycling rate.
Schools
University of Washington
Procedures Preformed
- Ablation for Treatment of Cardiac Arrhythmias
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Imaging
- Cardiac Myocardial Perfusion Imaging
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Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Aneurysm
- Aortic Dissection
- Aortic Ectasia
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Doctors Specialties
- Cardiology
Accepted Insurances
Education
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Beth Israel Deaconess Medical Center -
University of Washington School of Medicine
Hospital
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Mayo Clinic - Rochester, Minnesota
Drug Facts
| NPI NUMBER | 1164408191 | |
| NPPES Provider LastName | BROZOVICH | |
| NPPES Provider FirstName | FRANK | |
| NPPES Provider ZIPCode | 559050001 | |
| NPPES Provider State | MN | |
| Specialty Description | Cardiology | |
| Total Claim Count | 192.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1164408191 |
| Last Name Of The Provider | BROZOVICH |
| First Name Of The Provider | FRANK |
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