Staff Physician, University of Michigan Medical Group
Gastroenterology
Dr. John M. Carethers, MD
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John Carethers is an expert in the field of Gastroenterology. He researched medicine at Wayne State University School of Medicine. Wayne State University School of Medicine has a rank of 63 in research and a 85 in primary care He has 9 awards "Distinguished Alumni Award", "Elected Member", "Laureate Award", "Ambassador Award", "Vice Chancellor's Award for Mentoring Excellence", "Fellow", "CMS Meaningful Use Stage 1 Certification", "Fellow (AGAF)" and "Fellow (FACG)". John Carethers is a published doctor and has 83 publications published. The lastest was: 'Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome.'
Publications
- Reducing Colorectal Cancer Risk Among African Americans.
- Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer.
- Efficacy of Adjuvant 5-Fluorouracil Therapy for Patients with EMAST-Positive Stage II/III Colorectal Cancer.
- EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression.
- Screening for Colorectal cancer in African Americans: determinants and rationale for an earlier age to commence screening.
- The United States System for Training of Gastroenterologists in Oncology.
- Molecular Subtyping of Colorectal Cancer: Time to Explore Both Intertumoral and Intratumoral Heterogeneity to Evaluate Patient Outcome.
- Current and Future Role of the Gastroenterologist in GI Cancer Management.
- Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells.
- The imperative to invest in science has never been greater.
- Differentiating lynch-like from lynch syndrome.
- DNA Testing and Molecular Screening for Colon Cancer.
- Toward a comprehensive and Systematic methylome signature in colorectal cancers.
- Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity.
- Oxidative Stress Induces Nuclear-to-Cytosol Shift of hMSH3, a Potential Mechanism for EMAST in Colorectal Cancer Cells.
- Bridging behavior and biology to reduce socioeconomic disparities in Colorectal cancer risk.
- Proteomics, Genomics, and Molecular Biology in the Personalized Treatment of Colorectal Cancer.
- DNA mismatch repair proficiency executing 5-fluorouracil cytotoxicity in Colorectal cancer cells.
- Flanking nucleotide specificity for DNA mismatch repair-deficient frameshifts within Activin Receptor 2 (ACVR2).
- Microsatellite instability, EMAST, and morphology associations with T cell infiltration in Colorectal neoplasia.
- One Colon Lumen but Two Organs.
- Our new president-C. Richard boland, MD.
- Evidence for an hMSH3 defect in familial hamartomatous polyps.
- Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon Cancer.
- Both hMutS? and hMutS?? DNA Mismatch Repair Complexes Participate in 5-Fluorouracil Cytotoxicity.
- John Cunningham virus T-antigen expression in anal carcinoma.
- Cyclin E and histone H3 levels are regulated by 5-fluorouracil in a DNA mismatch repair-dependent manner.
- Molecular mechanisms underlying Ca2+-mediated motility of human pancreatic duct cells.
- Microsatellite alterations at selected tetranucleotide repeats are associated with morphologies of Colorectal neoplasias.
- Relationship of EMAST and microsatellite instability among patients with rectal Cancer.
- A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.
- Mesalazine reduces mutations in transforming growth factor beta receptor II and activin type II receptor by improvement of replication fidelity in mononucleotide repeats.
- TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic Cancer cells.
- Secondary Prevention of Colorectal Cancer: Is There an Optimal Follow-up for Patients with Colorectal Cancer?
- Multiple "apple-core" lesions in chronic ischemic colitis: the great masquerader.
- Intersection of transforming growth factor-beta and Wnt signaling pathways in Colorectal cancer and metastasis.
- Activin signaling in microsatellite stable colon Cancers is disrupted by a combination of genetic and epigenetic mechanisms.
- TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon Cancer cells.
- Genomic and epigenetic instability in Colorectal cancer pathogenesis.
- TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic Cancer cells.
- Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair.
- Starting your first faculty position.
- Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon Cancer.
- BMP suppresses PTEN expression via RAS/ERK signaling.
- Cyclooxygenase-2 expression in polyps from a patient with juvenile polyposis syndrome with mutant BMPR1A.
- Activin type 2 receptor restoration in MSI-H colon Cancer suppresses growth and enhances migration with activin.
- Bone morphogenetic protein signaling and growth suppression in colon Cancer.
- Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon Cancers.
- Peritoneal mice implicated in intestinal obstruction: report of a case and review of the literature.
- Unwinding the heterogeneous nature of hamartomatous polyposis syndromes.
- Clinicopathological features and microsatellite instability (MSI) in Colorectal cancers from African Americans.
- Serrated adenomas have a pattern of genetic alterations that distinguishes them from other Colorectal polyps.
- 5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon Cancer.
- Diet, lifestyle, and genomic instability in the North Carolina Colon Cancer Study.
- Nuclear accumulation of beta-catenin occurs commonly in the epithelial cells of juvenile polyps.
- The mismatch repair complex hMutS alpha recognizes 5-fluorouracil-modified DNA: implications for chemosensitivity and resistance.
- NOD2 and Colorectal cancer: guilt by non-association.
- Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic Colorectal cancers.
- Loss of activin receptor type 2 protein expression in microsatellite unstable colon Cancers.
- Use of 5-fluorouracil and survival in patients with microsatellite-unstable Colorectal cancer.
- Aphthous colitis in a young man with diverticulitis.
- Characterization of sporadic colon Cancer by patterns of genomic instability.
- High incidence of microsatellite instability in Colorectal cancer from African Americans.
- Occult gastrointestinal bleeding and colonic mass lesion as initial presentation of renal cell carcinoma.
- Oxidative stress inactivates the human DNA mismatch repair System.
- Comparison of microsatellite instability and chromosomal instability in predicting survival of patients with T3N0 Colorectal cancer.
- Hamartomatous polyposis syndromes: genetic pathways.
- Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome.
- Prognostic significance of allelic lost at chromosome 18q21 for stage II Colorectal cancer.
- Localization of the Bannayan-Riley-Ruvalcaba syndrome gene to chromosome 10q23.
- The cellular and molecular pathogenesis of Colorectal cancer.
- Massive secretory diarrhea and pseudo-obstruction as the initial presentation of Crohn's disease.
- Competency in mismatch repair prohibits clonal expansion of Cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.
- In vitro transcription/translation assay for the screening of hMLH1 and hMSH2 mutations in familial colon Cancer.
- Evidence for a connection between the mismatch repair System and the G2 cell cycle checkpoint.
- Delayed gastric emptying after laparoscopic anterior highly selective and posterior truncal vagotomy.
- Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells w...
- Images in clinical medicine. Extraintestinal manifestations of Crohn's disease.
- The epidemiology of methicillin-resistant Staphylococcus aureus in a burn center.
- Experimental and clinical observations on frostbite.
- Influence of Race on Microsatellite Instability and CD8+ T Cell Infiltration in Colon Cancer.
- Microsatellite Alterations With Allelic Loss at 9p24.2 Signify Less-Aggressive Colorectal Cancer Metastasis.
Schools
Wayne State University
Ma Genl Hospital Harvard Med School
University Mi Med School
Conditions Treated
- Anemia
- Benign Neoplasm of the Digestive System
- Colorectal Cancer
Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Distinguished Alumni Award
- Elected Member
- Laureate Award
- Ambassador Award
- Vice Chancellor's Award for Mentoring Excellence
- Fellow
- CMS Meaningful Use Stage 1 Certification
- Fellow (AGAF)
- Fellow (FACG)
Education
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University of Michigan Hospitals and Health Centers -
Massachusetts General Hospital -
Wayne State University School of Medicine
Hospital
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University of Michigan Hospitals and Health Centers
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