Professor, Pediatrics - Hematology and Oncology, Stanford University Medical Center
Pediatric Hematology & Oncology
Dr. Kathleen Sakamoto, MD
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Kathleen Sakamoto practices Pediatric Hematology & Oncology. She studied medicine at University of Cincinnati College of Medicine. She has 4 awards "America's Top Doctors", "America's Top Doctors for Cancer", "Top Doctors:Southern California" and "Super Doctor". Dr. Kathleen Sakamoto has written publications. She has 77 publications published with PubMed. The lastest publication is: 'Small molecule screen for inhibitors of expression from canonical CREB response element-containing promoters.'
Publications
- Small molecule screen for inhibitors of expression from canonical CREB response element-containing promoters.
- Replication factor C3 is a CREB Target gene that regulates Cell cycle progression through modulation of chromatin loading of PCNA.
- TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19 deficient hematopoietic progenitors.
- The role of DNA damage response in zebrafish and cellular models of Diamond Blackfan Anemia.
- Letting microRNAs overcome resistance to chemotherapy in Acute myeloid leukemia.
- Abstracts of Presentations at the International Conference on Basic and Clinical Multimodal Imaging (BaCI), a Joint Conference of the International Society for Neuroim...
- Increased Abscess Formation and Defective Chemokine Regulation in CREB Transgenic Mice.
- Identification of somatic and germline mutations using whole exome sequencing of congenital Acute lymphoblastic leukemia.
- The functions of RPS19 and their relationship to Diamond-Blackfan Anemia: a review.
- Chemical genetic control of protein levels: selective in vivo targeted degradation.
- Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability.
- CREB and leukemogenesis.
- Preface: special issue on critical reviews in leukemogenesis.
- Balancing work and life: an interview with Kathleen Sakamoto.
- Becoming a woman physician scientist.
- CREB in the pathophysiology of Cancer: implications for targeting transcription factors for Cancer therapy.
- p53 family in development.
- Expression profile of CREB knockdown in myeloid Leukemia cells.
- Role of p53 family in birth defects: lessons from zebrafish.
- Transplantation for congenital bone marrow failure syndromes.
- The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic Malignancies.
- Editorial: granulopoiesis versus monopoiesis: a consequence of transcription factors dancing with the right partners.
- Tubacin suppresses proliferation and induces apoptosis of Acute lymphoblastic leukemia cells.
- The multitargeted receptor tyrosine kinase inhibitor linifanib (ABT-869) induces apoptosis through an Akt and glycogen synthase kinase 3?-dependent pathway.
- Increasing diversity in pediatric hematology/oncology.
- Self-renewal of Acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.
- Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects.
- The role of the transcription factor CREB in immune function.
- The role of HDAC6 in Cancer.
- Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic Leukemia.
- Macroautophagy modulates cellular response to proteasome inhibitors in Cancer therapy.
- Targeting CREB for Cancer therapy: friend or foe.
- ABT-869 inhibits the proliferation of Ewing Sarcoma Cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways.
- Protacs for treatment of Cancer.
- CREB: A Key Regulator of Normal and Neoplastic Hematopoiesis.
- Congenital Disorders of ribosome biogenesis and bone marrow failure.
- Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family.
- The aggresome pathway as a target for therapy in hematologic Malignancies.
- Role of the aggresome pathway in Cancer: targeting histone deacetylase 6-dependent protein degradation.
- CREB is a critical regulator of normal hematopoiesis and leukemogenesis.
- Cancer stem cells: the root of the problem.
- A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish.
- PEG-asparaginase.
- Potential role of CREB as a prognostic marker in Acute myeloid leukemia.
- Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006.
- ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in Acute myeloid leukemia.
- Targeting ubiquitinylation for drug discovery.
- BUBR1 deficiency results in abnormal megakaryopoiesis.
- RNA interference and human Disease.
- Development of Protacs to target Cancer-promoting proteins for ubiquitination and degradation.
- The role of p55CDC in Cell cycle control and mammalian Cell proliferation, differentiation, and apoptosis.
- Transcriptional regulators and myelopoiesis: the role of serum response factor and CREB as targets of cytokine signaling.
- Ubiquitin-dependent proteolysis: its role in human Diseases and the design of therapeutic strategies.
- Cell surface antigen and molecular targeting in the treatment of hematologic Malignancies.
- Expression of cyclic adenosine monophosphate response-element binding protein in Acute leukemia.
- Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM Cells.
- FMS-like tyrosine kinase 3 in normal hematopoiesis and Acute myeloid leukemia.
- Topics in pediatric Leukemia--Fanconi's anemia: new insights.
- Topics in pediatric leukemia--Acute lymphoblastic leukemia.
- Topics in pediatric leukemia--Acute lymphoblastic leukemia and late effects in long-term survivors.
- Topics in pediatric Leukemia--myelodysplastic and myeloproliferative disorders of childhood.
- Topics in pediatric Leukemia--hematopoietic stem cell transplantation.
- Chimeric molecules to target proteins for ubiquitination and degradation.
- Academic training pathways in pediatric hematology-oncology.
- Role of cyclic AMP response element binding protein in human Leukemias.
- The genetic basis of bone marrow failure syndromes in children.
- The role of CREB as a proto-oncogene in hematopoiesis.
- The role of CREB as a proto-oncogene in hematopoiesis and in Acute myeloid leukemia.
- Su-11248 Sugen.
- G-CSF induces stabilization of ETS protein Fli-1 during myeloid Cell development.
- Severe lactic acidosis in a 14-year-old female with metastatic undifferentiated carcinoma of unknown primary.
- The emerging role of RNA interference in the design of novel therapeutics in oncology.
- Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain.
- Comparison of bone marrow aspirates and biopsies in pediatric patients with ALL at days 7 and 14 of induction therapy.
- Knocking down human Disease: potential uses of RNA interference in research and gene therapy.
- The role of cyclic-AMP binding protein (CREB) in leukemia cell proliferation and Acute leukemias.
Schools
University Of Cincinnati College Of Medicine
Chldns Hospital Of Los Angeles
Conditions Treated
- Acute Leukemia
- Anemia
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Cancer
- View All
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- America's Top Doctors
- America's Top Doctors for Cancer
- Top Doctors:Southern California
- Super Doctor
Education
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Children's Hospital of Los Angeles -
University of Cincinnati College of Medicine
Hospital
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Lucile Packard Children's Hospital Stanford -
Ronald Reagan UCLA Medical Center -
Stanford Health Care
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