Instructor in Pediatrics, Dana-Farber Cancer Institute
Pediatric Hematology & Oncology
Dr. Kathrin M. Bernt, MD
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Kathrin Bernt practices Pediatric Hematology & Oncology. Dr. Kathrin M. Bernt has written publications. She has 26 publications published with PubMed. The lastest paper is: 'Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.'
Publications
- Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.
- Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.
- DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
- AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes.
- HDAC expression patterns in pediatric ALL.
- DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions.
- Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l.
- Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor.
- MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L.
- Targeting Epigenetic Programs in MLL-Rearranged Leukemias.
- Eradication of CD19+ leukemia by targeted calicheamicin θ.
- Leukemia stem cells and human acute lymphoblastic leukemia.
- Assessment of a combined, adenovirus-mediated oncolytic and immunostimulatory tumor therapy.
- A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases.
- The effect of sequestration by nontarget Tissues on anti-tumor efficacy of systemically applied, conditionally replicating adenovirus vectors.
- Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia.
- Enzyme-activated Prodrug Therapy Enhances Tumor-specific Replication of Adenovirus Vectors.
- Human milk and the response of intestinal epithelium to infection.
- Evaluation of biodistribution and safety of adenovirus vectors containing group B fibers after intravenous injection into baboons.
- A new type of adenovirus vector that utilizes homologous recombination to achieve tumor-specific replication.
- A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells.
- Synthesis, hydrolytic activation and cytotoxicity of etoposide prodrugs.
- Human milk as a carrier of biochemical messages.
- A role for DOT1L in MLL-rearranged leukemias.
Schools
Humboldt University Med School
Children39s Hospital
Texas Children39s Hospital
Dana Farber Cancer Institute
Procedures Preformed
- HPC Transplantation (Stem Cell Transplant)
Conditions Treated
- Anemia
- Lymphoma
- Lymphosarcoma
- Soft Tissue Sarcoma
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Education
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Boston Children's Hospital -
University of Washington -
Humboldt University of Berlin- Charite Faculty of Medicine
Hospital
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Children's Hospital Colorado
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