Professor of Obstetrics and Gynecology, University Iowa College of Medicine
Obstetrics & Gynecology
Dr. Kimberly Leslie, MD
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Kimberly Leslie works in the field of Obstetrics & Gynecology. He went to medical school at University of Texas Southwestern Medical School. He received 1 awards: "Fellow (FACOG)". Kimberly Leslie is a published MD. He published 83 publications, including: 'Selective down-regulation of progesterone receptor isoform B in poorly differentiated human endometrial cancer cells: implications for unopposed estrogen action.'
Publications
- Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.
- Introduction to the American Heart Association's Hypertension Strategically Focused Research Network.
- Downregulation of FOXO1 mRNA levels predicts treatment failure in patients With endometrial pathology conservatively managed With progestin-containing intrauterine dev...
- NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling.
- Genetic Deficiency of Mtdh in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs.
- [49-OR]: Vasopressin secretion in human Pregnancy predicts the development of preeclampsia as early as the sixth week of gestation.
- BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway.
- Histologic effects of medroxyprogesterone acetate on endometrioid endometrial adenocarcinoma: a gynecologic oncology group study.
- TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based standard chemotherapy in patients diagnosed With advanced serous ovarian carcinoma.
- A Phase II Evaluation of Nintedanib (BIBF-1120) in the Treatment of Recurrent or Persistent Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study.
- Hepatitis B and C in Pregnancy: a review and recommendations for care.
- Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer.
- "Collection of a lifetime: A practical approach to developing a longitudinal collection of women's healthcare biological samples".
- microRNA expression patterns across seven cancers are highly correlated and dominated by evolutionarily ancient families.
- Comprehensive Profiling of EGFR/HER Receptors for Personalized Treatment of Gynecologic Cancers.
- Temsirolimus With or Without megestrol acetate and tamoxifen for endometrial cancer: A gynecologic oncology group study.
- Epigenetic Modification Restores Functional PR Expression in Endometrial Cancer Cells.
- Induction of mitotic cell death by overriding G2/M checkpoint in endometrial cancer cells With non-functional p53.
- A phase II evaluation of gefitinib in the treatment of persistent or recurrent endometrial cancer: A Gynecologic Oncology Group study.
- Identification of a novel mechanism of NF-kappaB inactivation by progesterone through progesterone receptors in Hec50co poorly differentiated endometrial cancer cells:...
- Immunomodulatory and transcriptional effects of progesterone through progesterone A and B receptors in Hec50co poorly differentiated endometrial cancer cells.
- Progesterone receptor isoform identification and subcellular localization in endometrial cancer.
- A therapeutic model for advanced endometrial cancer: systemic progestin in combination With local adenoviral-mediated progesterone receptor expression.
- Obstetric forceps training using visual feedBack and the isometric strength testing unit.
- A potential synergistic anticancer effect of paclitaxel and amifostine on endometrial cancer.
- Strategies for Molecularly Enhanced Chemotherapy to Achieve Synthetic Lethality in Endometrial Tumors With Mutant p53.
- Gene regulation profiles by progesterone and dexamethasone in Human endometrial cancer Ishikawa H cells.
- Chemotherapeutic drugs in Pregnancy.
- Oral contraceptives and skin cancer: is there a link?
- Regulation of signaling phosphoproteins by epidermal growth factor and Iressa (ZD1839) in Human endometrial cancer cells that model type I and II tumors.
- Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG.
- GPR30: a novel indicator of poor survival for endometrial carcinoma.
- Identification of proteins Within the nuclear factor-kappa B transcriptional complex including estrogen receptor-alpha.
- Consequences of the loss of p53, RB1, and PTEN: relationship to gefitinib resistance in endometrial cancer.
- Models representing type I and type II Human endometrial cancers: Ishikawa H and Hec50co cells.
- Relationship of estrogen and progesterone receptors to clinical outcome in metastatic endometrial carcinoma: a Gynecologic Oncology Group Study.
- Targeted treatment using monoclonal antibodies and tyrosine-kinase inhibitors in Pregnancy.
- The oncoPlacental gene Placenta-specific protein 1 is highly expressed in endometrial tumors and cell lines.
- Effect of tamoxifen on endometrial histology, hormone receptors, and cervical cytology: a prospective study With follow-up.
- Chronic hepatitis C in Pregnancy.
- EGFR isoforms and gene regulation in Human endometrial cancer cells.
- Amifostine enhancement of the anti-cancer effects of paclitaxel in endometrial cancer is TP53-dependent.
- Effects of bevacizumab in mouse model of endometrial cancer: Defining the molecular basis for resistance.
- Progesterone: the ultimate endometrial tumor suppressor.
- Phase II trial of bevacizumab in recurrent or persistent endometrial cancer: a Gynecologic Oncology Group study.
- Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment.
- microRNA expression profiling of endometrial endometrioid adenocarcinomas and serous adenocarcinomas reveals profiles containing shared, unique and differentiating gro...
- An inhibitor of K+ channels modulates Human endometrial tumor-initiating cells.
- Placenta-specific protein 1: a potential key to many oncofetal-Placental OB/GYN research questions.
- Cadherins, catenins and cell cycle regulators: impact on survival in a Gynecologic Oncology Group phase II endometrial cancer trial.
- Endometrial cancer: reviving progesterone therapy in the molecular age.
- A phase II evaluation of lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A gynecologic oncology group study.
- A mechanism for synergy With combined mTOR and PI3 kinase inhibitors.
- Cytoplasmic Metadherin (MTDH) Provides Survival Advantage under Conditions of Stress by Acting as RNA-binding Protein.
- Endometrial cancer: potential treatment and prevention With progestin-containing intrauterine devices.
- Histologic inflammation in the maternal and fetal compartments in a rabbit model of acute intra-amniotic infection.
- Molecular tools to reestablish progestin control of endometrial cancer cell proliferation.
- Selective down-regulation of progesterone receptor isoform B in poorly differentiated Human endometrial cancer cells: implications for unopposed estrogen action.
- Acute intrauterine infection results in an imbalance between pro- and anti-inflammatory cytokines in the pregnant rabbit.
- Differential expression of the A and B isoforms of progesterone receptor in Human endometrial cancer cells. Only progesterone receptor B is induced by estrogen and ass...
- A randomized controlled trial of interleukin-1 receptor antagonist in a rabbit model of ascending infection in Pregnancy.
- Endocrine cancer risks for women During the perimenopause and beyond.
- Low serum estradiol and high serum progesterone concentrations characterize hypertensive Pregnancies at high altitude.
- Estrogen receptors are identified in the glioblastoma cell line U138MG.
- T47DCO cells, genetically unstable and containing estrogen receptor mutations, are a model for the progression of breast cancers to hormone resistance.
- Estrogens in intrahepatic cholestasis of Pregnancy.
- The Estrogen Receptor Joins Other Cancer Biomarkers as a Predictor of Outcome.
- Functional analysis of a mutant estrogen receptor isolated from T47Dco breast cancer cells.
- Estrogen receptors are present in Human granulosa cells.
- Blocking Epidermal Growth Factor Receptor Signaling in HTR-8/SVneo First Trimester Trophoblast Cells Results in Dephosphorylation of PKB?/AKT and Induces Apoptosis.
- Differential gene expression in the amnion, chorion, and trophoblast of the Human placenta.
- The role of oestrogen in follicular development.
- Pregnancy specific beta 1 glycoprotein (SP-1) in maternal serum and amniotic fluid; pre-eclampsia, small for Gestational age fetus and fetal distress.
- Oestrogen modulation With parturition in the human placenta.
- Drug Resistance Mediated by AEG-1/MTDH/LYRIC.
- Past, present, and future of hormonal therapy in recurrent endometrial cancer.
- The Consequence of Oncomorphic TP53 Mutations in Ovarian Cancer.
- Progesterone inhibits Human endometrial cancer cell growth and invasiveness: down-regulation of cellular adhesion molecules through progesterone B receptors.
- Chronic intrauterine infection and inflammation in the preterm rabbit, despite antibiotic therapy.
- Chemotherapy and Pregnancy.
- Progesterone regulation of activating protein-1 transcriptional activity: a possible mechanism of progesterone inhibition of endometrial cancer cell growth.
- Tumor mutational analysis of GOG248, a phase II study of temsirolimus or temsirolimus and alternating megestrol acetate and tamoxifen for advanced endometrial cancer (...
Schools
University of Texas Southwestern Medical Center At Dallas
Parkland Memorial Hospital
Georgetown University
Procedures Preformed
- C-Section
Conditions Treated
- Encounters for High-Risk Pregnancies
- Gestational Diabetes
- Hematologic Abnormalities Associated Background: yellow;'>Background: yellow;'>Background: yellow;'>Background: yellow;'>Background: yellow;'>With Background: yellow;'>Background: yellow;'>Pregnancy
- HPV (Human Papillomavirus)
- View All
Doctors Specialties
- Maternal-Fetal Medicine
- Obstetrics
- Gynecology
Accepted Insurances
- Choice Plus POS II
- Assurant Health
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Blue Cross Accord
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- Coventry Health Care of Illinois PPO
- First Health (Coventry Health Care) PPO
- Golden Rule
- Health Alliance PPO
- Choice Care PPO
- Medicare MCR
- Principal Life
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
- Alliance Select
Awards
- Fellow (FACOG)
Education
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Georgetown University Hospital -
University of Texas Southwestern Medical School
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