Physician
Pathology
Dr. Laura Manuelidis, MD
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Laura Manuelidis is an expert in the field of Pathology. Laura Manuelidis is also published. He has 37 publications published. The lastest publication: "The dimensions of Creutzfeldt-Jakob disease.'
Publications
- Rapid chemical decontamination of infectious CJD and scrapie particles parallels treatments known to disrupt microbes and biofilms.
- Highly infectious CJD particles lack prion protein but contain many viral-linked peptides by LC-MS/MS.
- Infectious particles, stress, and induced prion amyloids: A unifying perspective.
- Continuous production of prions after infectious particles are eliminated: implications for Alzheimer's disease.
- High CJD infectivity remains after prion protein is destroyed.
- Replication and spread of CJD, kuru and scrapie agents in vivo and in cell culture.
- Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJD.
- Proliferative arrest of neural cells induces prion protein synthesis, nanotube formation, and cell-to-cell contacts.
- Transmissible encephalopathy agents: virulence, geography and clockwork.
- Agent-specific Shadoo responses in transmissible encephalopathies.
- The kuru infectious agent is a unique geographic isolate distinct from Creutzfeldt-Jakob disease and scrapie agents.
- Strain-specific viral properties of variant Creutzfeldt-Jakob disease (vCJD) are encoded by the agent and not by host prion protein.
- A rapid accurate culture assay for infectivity in Transmissible Encephalopathies.
- Quantitative recovery of scrapie agent with minimal protein from highly infectious cultures.
- A 25 nm virion is the likely cause of transmissible spongiform encephalopathies.
- Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles.
- A virus behind the mask of prions?
- Reciprocal interference between specific CJD and scrapie agents in neural cell cultures.
- New molecular markers of early and progressive CJD brain infection.
- Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell cultures.
- Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease.
- Transmissible encephalopathies: speculations and realities.
- Virus-like interference in the latency and prevention of Creutzfeldt-Jakob disease.
- Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease.
- Microglia from Creutzfeldt-Jakob disease-infected brains are infectious and show specific mRNA activation profiles.
- Transient appearance of amyloid precursor protein plaques in the brain of thymectomized rats after human leptomeningeal cell grafts.
- The dimensions of Creutzfeldt-Jakob disease.
- Reproducible compartmentalization of individual chromosome domains in human CNS cells revealed by in situ hybridization and three-dimensional reconstruction.
- Movement of the X chromosome in epilepsy.
- Potential involvement of retroviral elements in human dementias.
- Growth factor production by Creutzfeldt-Jakob disease cell lines.
- Suggested links between different types of dementias: Creutzfeldt-Jakob disease, Alzheimer disease, and retroviral CNS infections.
- Heterochromatic features of an 11-megabase transgene in brain cells.
- Nuclease treatment results in high specific purification of Creutzfeldt-Jakob disease infectivity with a density characteristic of nucleic acid-protein complexes.
- Nuclease-resistant polyadenylated RNAs of significant size are detected by PCR in highly purified Creutzfeldt-Jakob disease preparations.
- Analysis of Creutzfeldt-Jakob disease infectious fractions by gel permeation chromatography and sedimentation field flow fractionation.
Schools
Yale University
Yale University School Of Med
Doctors Specialties
- Pathology
Accepted Insurances
- Commercial Insurance Company
- Medicare MCR
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