Assistant Professor of Medicine, Massachusetts General Hospital
Infectious Disease
Dr. Marylyn M. Addo, MD
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Marylyn M. Addo, MD works in the field of Infectious Disease. Marylyn Addo is a published doctor and has 69 publications published. The lastest was: 'Reactivation of hepatitis B in a long-term anti-HBs-positive patient with AIDS following lamivudine withdrawal.'
Publications
- Sex-Based Differences in HIV Type 1 Pathogenesis.
- HIV-1 infection impairs regulatory T cell suppressive capacity on a per-cell basis.
- Identification of HIV-1-specific regulatory T cells using HLA class II tetramers.
- Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion.
- CD4+ CD25+ Regulatory T cells Impair HIV-Specific CD4 T Cell Responses by Upregulating IL-10 Production in Monocytes.
- Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
- Regulatory T cell frequencies do not correlate with breadth or magnitude of HIV-1-specific T cell responses.
- Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals.
- The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
- Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers.
- Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells.
- Adaptation of HIV-1 to human leukocyte antigen class I.
- Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes.
- Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.
- Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
- Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection.
- HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.
- GB virus C (GBV-C) infection in hepatitis C virus (HCV)/HIV-coinfected patients receiving HCV treatment: importance of the GBV-C genotype.
- Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire.
- Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
- Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection.
- Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses.
- Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein.
- The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodom...
- Regulatory and accessory HIV-1 proteins: potential targets for HIV-1 vaccines?
- The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.
- Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
- IL-8 responsiveness defines a subset of CD8 T cells poised to kill.
- Limited durability of viral control following treated acute HIV infection.
- Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.
- Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells.
- HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha.
- HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity.
- CD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjects.
- Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recogniz...
- Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians.
- Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
- HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication.
- HIV evolution: CTL escape mutation and reversion after transmission.
- Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities.
- Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection.
- Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.
- Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.
- Augmentation of HIV-1-specific T helper cell responses in chronic HIV-1 infection by therapeutic immunization.
- Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses.
- Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate ...
- Rev activity determines sensitivity of HIV-1-infected primary T cells to CTL killing.
- HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.
- Cytotoxic T-lymphocyte (CTL) responses directed against regulatory and accessory proteins in HIV-1 infection.
- Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variat...
- Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.
- HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.
- Cellular immune responses in transplantation-associated chronic viral infections.
- Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
- Vpr is preferentially targeted by CTL during HIV-1 infection.
- Evolution and transmission of stable CTL escape mutations in HIV infection.
- Protease-activated receptor-2 (PAR-2): structure-function study of receptor activation by diverse peptides related to tethered-ligand epitopes.
- The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.
- Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-bindin...
- Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staini...
- Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.
- Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.
- Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immu...
- T(H)1 to T(H)2 shift of cytokines in peripheral blood of HIV-infected patients is detectable by reverse transcriptase polymerase chain reaction but not by enzyme-linke...
- Influence of protease inhibitor therapy on lipoprotein metabolism.
- Reactivation of hepatitis B in a long-term anti-HBs-positive patient with AIDS following lamivudine withdrawal.
- Regulatory T Cells Expanded from HIV-1-Infected Individuals Maintain Phenotype, TCR Repertoire and Suppressive Capacity.
- Dysregulated Tim-3 expression on natural killer cells is associated with increased Galectin-9 levels in HIV-1 infection.
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Education
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Massachusetts General Hospital -
University of Bonn Faculty of Medicine
Hospital
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Massachusetts General Hospital
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