Professor, Pediatrics, UCSF School of Medicine
Pediatric Hematology & Oncology
Dr. Mignon L. Loh, MD
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Mignon L. Loh, MD is an expert in the field of Pediatric Hematology & Oncology. He attended Columbia University College of Physicians & Surgeons. Columbia University College of Physicians & Surgeons is a top medical college. Columbia University College of Physicians & Surgeons is ranked 8/52 in Research/PrimaryCare. Mignon is a published MD. He published 101 publications, including: 'Incidence of TEL/AML1 fusion in children with relapsed acute lymphoblastic leukemia.'
Publications
- Genetic risk factors for the development of osteonecrosis in children under age 10 treated for Acute lymphoblastic leukemia.
- MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric Leukemia.
- The genomic landscape of juvenile myelomonocytic Leukemia.
- Germline genetic variation in ETV6 and risk of childhood Acute lymphoblastic leukaemia: a systematic genetic study.
- Genetics of glucocorticoid-associated osteonecrosis in children with Acute lymphoblastic leukemia.
- Phase II/III trial of a pre-transplant farnesyl transferase inhibitor in juvenile myelomonocytic Leukemia: A report from the Children's Oncology Group.
- Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) Acute lymphoblastic leukemia.
- Safe integration of nelarabine into intensive chemotherapy in newly diagnosed T-cell Acute lymphoblastic leukemia: Children's Oncology Group Study AALL0434.
- Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia.
- Signalling thresholds and negative B-cell selection in Acute lymphoblastic leukaemia.
- Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with Acute lymphoblastic leukemia.
- Pharmacokinetic and Pharmacodynamic Properties of Calaspargase Pegol Escherichia coli L-Asparaginase in the Treatment of Patients With Acute Lymphoblastic Leukemia: Re...
- A genome-wide association study of susceptibility to Acute lymphoblastic leukemia in adolescents and young adults.
- An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.
- Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic Leukemia.
- Decreased induction morbidity and mortality following modification to induction therapy in infants with Acute lymphoblastic leukemia enrolled on AALL0631: A report fro...
- Bedside to bench in juvenile myelomonocytic Leukemia: insights into leukemogenesis from a rare pediatric Leukemia.
- HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.
- PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML.
- Mutations in GATA2 are rare in juvenile myelomonocytic Leukemia.
- Inherited GATA3 variants are associated with Ph-like childhood Acute lymphoblastic leukemia and risk of relapse.
- Identification of Cryptotanshinone as an Inhibitor of Oncogenic Protein Tyrosine Phosphatase SHP2 (PTPN11).
- Targeting Protein Tyrosine Phosphatase SHP2 for the Treatment of PTPN11-Associated Malignancies.
- Genetic predispositions to childhood Leukemia.
- Intrachromosomal Amplification of Chromosome 21 Is Associated With Inferior Outcomes in Children With Acute Lymphoblastic Leukemia Treated in Contemporary Standard-Ris...
- Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic Leukemia.
- Associations between genome-wide Native American ancestry, known risk alleles and B-Cell ALL risk in Hispanic children.
- Novel Susceptibility Variants at 10p12.31-12.2 for Childhood Acute Lymphoblastic Leukemia in Ethnically Diverse Populations.
- Genome-wide study of methotrexate clearance replicates SLCO1B1.
- Deficiency of CREB and Over-expression of miR-183 in Juvenile Myelomonocytic Leukemia.
- The thirteenth international childhood Acute lymphoblastic leukemia workshop report: La Jolla, CA, USA, December 7-9, 2011.
- The genomic landscape of hypodiploid Acute lymphoblastic leukemia.
- Integrin alpha4 blockade sensitizes drug resistant pre-B Acute lymphoblastic leukemia to chemotherapy.
- Tyrosine kinome sequencing of pediatric Acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project.
- Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor Acute lymphoblastic leukemia.
- Advances in the genetics of high-risk childhood B-progenitor Acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy.
- Key pathways are frequently mutated in high risk childhood Acute lymphoblastic leukemia: a report from the Children's Oncology Group.
- Improving outcomes for high-risk ALL: translating new discoveries into clinical care.
- Understanding the Biology of CRLF2-Overexpressing Acute Lymphoblastic Leukemia.
- Outcome for children treated for relapsed or refractory Acute myelogenous leukemia (rAML): a Therapeutic Advances in Childhood Leukemia (TACL) Consortium study.
- Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic Leukemia.
- Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell Acute lymphoblastic leukemia.
- Outcome of patients treated for relapsed or refractory Acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium study.
- Childhood myelodysplastic syndrome: focus on the approach to diagnosis and treatment of juvenile myelomonocytic Leukemia.
- Mutations in CBL occur frequently in juvenile myelomonocytic Leukemia.
- JAK mutations in high-risk childhood Acute lymphoblastic leukemia.
- A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene.
- JAK2 V617F positive polycythemia Vera in a child with neurofibromatosis type I.
- Single-cell profiling identifies aberrant STAT5 activation in myeloid Malignancies with specific clinical and biologic correlates.
- SOS1 mutations are rare in human Malignancies: implications for Noonan Syndrome patients.
- Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic Leukemia.
- Favorable outcome for adolescents with Acute lymphoblastic leukemia treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Protocols.
- Risk- and response-based classification of childhood B-precursor Acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Gr...
- Prospective analysis of TEL/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01.
- Inherited predispositions and hyperactive Ras in myeloid leukemogenesis.
- Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura.
- Cytogenetics of Hispanic and White children with Acute lymphoblastic leukemia in California.
- Congenital Leukemia cutis with subsequent development of Leukemia.
- The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and Acute myeloid leukemia, but not in Acute lymphoblastic leukemia or chronic lymphocytic ...
- The mutational spectrum of PTPN11 in juvenile myelomonocytic Leukemia and Noonan syndrome/myeloproliferative disease.
- Functional analysis of Leukemia-associated PTPN11 mutations in primary hematopoietic cells.
- Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult Acute myelogenous leukemia.
- Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis.
- SHP-2 and myeloid Malignancies.
- Prenatal origin of TEL-AML1-positive Acute lymphoblastic leukemia in children born in California.
- Treatment of infantile fibrosarcoma with chemotherapy and surgery: results from the Dana-Farber Cancer Institute and Children's Hospital, Boston.
- TEL/AML1-positive pediatric Leukemia: prognostic significance and therapeutic approaches.
- Gene expression signatures define novel oncogenic pathways in T cell Acute lymphoblastic leukemia.
- Integration of cytogenomic data for furthering the characterization of pediatric B-cell Acute lymphoblastic leukemia: a multi-institution, multi-platform microarray st...
- Rise and fall of subclones from diagnosis to relapse in pediatric B-Acute lymphoblastic leukaemia.
- Juvenile Myelomonocytic Leukemia: Molecular Pathogenesis Informs Current Approaches to Therapy and Hematopoietic Cell Transplantation.
- [The early pregnancy factor (EPF) as an early marker of Disorders in pregnancy].
- Outcome of very premature infants with necrotising enterocolitis cared for in centres with or without on site surgical facilities.
- Mutation analysis of Son of Sevenless in juvenile myelomonocytic Leukemia.
- Factors influencing survival after relapse from Acute lymphoblastic leukemia: a Children's Oncology Group study.
- Cancer: More than kin and less than kind.
- Congenital fibroSarcoma of the upper extremity.
- ARID5B Genetic Polymorphisms Contribute to Racial Disparities in the Incidence and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia.
- Stat5 is essential for the myelo- and lymphoproliferative Disease induced by TEL/JAK2.
- Molecular classification of Cancer: class discovery and class prediction by gene expression monitoring.
- PTPN11 mutations in pediatric patients with Acute myeloid leukemia: results from the Children''s Cancer Group.
- Targeting survivin overcomes drug resistance in Acute lymphoblastic leukemia.
- Ancestry and pharmacogenomics of relapse in Acute lymphoblastic leukemia.
- Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop Acute myelogenous leukaemia.
- Accurate detection of uniparental disomy and microdeletions by SNP array analysis in Myelodysplastic syndromes with normal cytogenetics.
- Translocation (2;8)(p12;q24) associated with a cryptic t(12;21)(p13;q22) TEL/AML1 gene rearrangement in a child with Acute lymphoblastic leukemia.
- Lack of TEL/AML1 fusion in pediatric AML: further evidence for lineage specificity of TEL/AML1.
- Incidence of TEL/AML1 fusion in children with relapsed Acute lymphoblastic leukemia.
- Ethnic difference in daycare attendance, early infections, and risk of childhood Acute lymphoblastic leukemia.
- Chromosome 12p deletions in TEL-AML1 childhood Acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally.
- Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic Leukemia.
- One year follow-up of children and adolescents with chronic immune thrombocytopenic purpura (ITP) treated with rituximab.
- Juvenile myelomonocytic Leukemia: a report from the 2nd International JMML Symposium.
- Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia.
- The genetic basis of early T-cell precursor Acute lymphoblastic leukaemia.
- Pediatric MDS: GATA screen the germline.
- MLL rearrangements impact outcome in HOXA-deregulated T-lineage Acute lymphoblastic leukemia: A children's oncology group study.
- Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia.
- KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
- A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor Acute lymphoblastic leukaemia aetiology.
Schools
Columbia University College Of Physicians and Surgeons
Children39s Hospital Boston
Dana Farber Cancer Institute
Conditions Treated
- Acute Leukemia
- Anemia
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Cancer
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Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
- Aetna HMO
- Basic HMO
- Choice Plus POS II
- Vitalidad Plus California Con Aetna
- Power Select HMO
- Blue Card PPO
- CaliforniaCare HMO
- Advantage Preferred DirectAccess Plus PPO
- Blue Cross Blue Shield of California PPO
- Pathway X Direct Access PPO
- Pathway X Tiered Direct Access
- Select Plus HMO
- Select PPO
- Access Plus Savenet
- Enhanced Exclusive for Small Business HMO
- Local Access Plus HMO
- Brown & Toland Physicians
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- Commercial Insurance Company
- Delta Health System
- First Health (Coventry Health Care) PPO
- Blue & Gold HMO
- Covered California - Bronze PPO
- Employer Group HMO
- Health Net PPO
- Individual and Family PPO
- WholeCare Network HMO
- Medicare MCR
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- PacifiCare HMO
- United Healthcare
Education
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Boston Children's Hospital -
UCSF -
Columbia University College of Physicians & Surgeons
Hospital
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UCSF Medical Center
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