Professor, Medicine, Perelman School of Medicine

Endocrinology

Nancy Cooke works in the field of Endocrinology. She studied medicine at Case Western Reserve University School of Medicine. She received awards:"Elected Member". Nancy Cooke is also a published doctor. She has 88 publication published. The most recent publication is: Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein.

Publications

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• Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.
• Long-range looping of a locus control region drives tissue-specific chromatin packing within a multigene cluster.
• Autonomous actions of the human growth hormone long-range enhancer.
• An auto-regulatory pathway establishes the definitive chromatin conformation at the Pit-1 locus.
• Tissue specific CTCF occupancy and boundary function at the human growth hormone locus.
• Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expression.
• Identification of a secondary promoter within the human B-cell receptor component gene, hCD79b.
• DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer function.
• An RNA-Independent Linkage of Noncoding Transcription to Long-Range Enhancer Function.
• The Role of the hGH Locus Control Region in Somatotrope Restriction of hGH-N Gene Expression.
• Research resource: T-antigen transformation of pituitary cells captures three novel cell lines in the Pit-1 lineage.
• Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo.
• An intronic locus control region plays an essential role in the establishment of an autonomous hepatic chromatin domain for the human vitamin D-binding protein gene.
• Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation.
• Igbeta(CD79b) mRNA expression in chronic lymphocytic leukaemia cells correlates with immunoglobulin heavy chain gene mutational status but does not serve as an indepen...
• A single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functions.
• Locus control region transcription plays an active role in long-range gene activation.
• Tissue-specific chromatin modifications at a multigene locus generate asymmetric transcriptional interactions.
• Neurobeachin is essential for neuromuscular synaptic transmission.
• Epigenetic modifications at the human growth hormone locus predict distinct roles for histone acetylation and methylation in placental gene activation.
• Activation of the human GH gene cluster: roles for targeted chromatin modification.
• Specification of unique Pit-1 activity in the hGH locus control region.
• 129X1/SvJ mouse strain has a novel defect in inflammatory cell recruitment.
• Structure of cloned DNA complementary to rat prolactin messenger RNA.
• Chronic lymphocytic leukaemia skin infiltrates affecting prominent parts of the face and the scalp.
• Structural analysis of the prolactin gene suggests a separate origin for its 5'' end.
• The prolactin gene is located on chromosome 6 in humans.
• Human prolactin. cDNA structural analysis and evolutionary comparisons.
• Human serum binding protein for vitamin D and its metabolites. II. Specific, high affinity association with a protein in nucleated tissue.
• Human serum binding protein for vitamin D and its metabolites. I. Physicochemical and immunological identification in human tissues.
• Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism.
• Molecular characterization of a major nephritogenic domain in the autoantigen of anti-tubular basement membrane disease.
• Expression of the prolactin gene in human decidua-chorion.
• The related genes encoding growth hormone and prolactin have been dispersed to chromosomes 10 and 17 in the rat.
• Vitamin D transport - the nature of the interaction between plasma DBP and tissue protein.
• Identification of the sterol- and actin-binding domains of plasma vitamin D binding protein (Gc-globulin).
• Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family.
• The rat vitamin D binding protein (Gc-globulin) gene is syntenic with the rat albumin and alpha-fetoprotein genes on chromosome 14.
• Rat vitamin D binding protein. Determination of the full-length primary structure from cloned cDNA.
• The vitamin D-binding protein, alpha-fetoprotein, albumin multigene family: detection of transcripts in multiple tissues.
• A high frequency MspI RFLP at the human vitamin D binding protein (hDBP) locus.
• Synthesis of growth hormone-prolactin chimeric proteins and processing mutants by the exchange and deletion of genomic exons.
• Binding of human growth hormone (GH)-variant (placental GH) to GH-binding proteins in human plasma.
• Complex alternative splicing partially inactivates the human chorionic somatomammotropin-like (hCS-L) gene.
• Vitamin D-binding protein. Structure and pattern of expression.
• Human growth hormone-variant is a biologically active somatogen and lactogen.
• Human growth hormone variant produces insulin-like and lipolytic responses in rat adipose tissue.
• Vitamin D binding protein (Gc-globulin).
• Vitamin D binding protein: genomic structure, functional domains, and mRNA expression in tissues.
• The LIM/double zinc-finger motif functions as a protein dimerization domain.
• Identification of a splice-site mutation in the human growth hormone-variant gene.
• Alternative splice site selection in the human growth hormone gene transcript and synthesis of the 20 kDa isoform: role of higher order transcript structure.
• Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism.
• A difference in the splicing patterns of the closely related normal and variant human growth hormone gene transcripts is determined by a minimal sequence divergence be...
• The rat vitamin D binding protein (Gc-globulin) gene. Structural analysis, functional and evolutionary correlations.
• Functional characterization of the alternatively spliced, placental human growth hormone receptor.
• Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif.
• Human growth hormone-variant demonstrates a receptor binding profile distinct from that of normal pituitary growth hormone.
• Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc.
• Developmental control and alternative splicing of the placentally expressed transcripts from the human growth hormone gene cluster.
• Electrophoretic mobility shift assay identifies vitamin D binding protein (Gc-globulin) in human, rat, and mouse sera.
• Molecular biology of the growth hormone-prolactin gene system.
• Alteration in the receptor binding specificity of human growth hormone by genomic exon exchange.
• Cell surface vitamin D-binding protein (GC-globulin) is acquired from plasma.
• Glycosylated human growth hormone variant.
• A native RNA secondary structure controls alternative splice-site selection and generates two human growth hormone isoforms.
• Characterization and histologic localization of human growth hormone-variant gene expression in the placenta.
• Human growth hormone gene and the highly homologous growth hormone variant gene display different splicing patterns.
• Physical linkage of the human growth hormone gene cluster and the skeletal muscle sodium channel alpha-subunit gene (SCN4A) on chromosome 17.
• Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins.
• Physical linkage of the human growth hormone gene cluster and the CD79b (Ig beta/B29) gene.
• Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster.
• The multifunctional properties and characteristics of vitamin D-binding protein.
• Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein.
• Targeted recruitment of histone acetyltransferase activity to a locus control region.
• The human growth hormone gene cluster locus control region supports position-independent pituitary- and placenta-specific expression in the transgenic mouse.
• Pit-1 binding sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gen...
• Vitamin D-binding protein gene transcription is regulated by the relative abundance of hepatocyte nuclear factors 1alpha and 1beta.
• Expression of a human growth hormone (hGH) receptor isoform is predicted by tissue-specific alternative splicing of exon 3 of the hGH receptor gene transcript.
• A defined locus control region determinant links chromatin domain acetylation with long-range gene activation.
• DNase I-hypersensitive sites I and II of the human growth hormone locus control region are a major developmental activator of somatotrope gene expression.
• The human growth hormone locus control region mediates long-distance transcriptional activation independent of nuclear matrix attachment regions.
• Patterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region.
• The human growth hormone gene is regulated by a multicomponent locus control region.
• Bystander gene activation by a locus control region.
• The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression.
• The human vitamin D-binding protein gene contains locus control determinants sufficient for autonomous activation in hepatic chromatin.

Schools

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• Case Western Reserve University School of Medicine

• Barnes Jewish Hospital

Doctors Specialties

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• Internal Medicine
• Endocrinology

Accepted Insurances

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Awards

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• Elected Member

Education

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• Washington University - Barnes-Jewish Hospital
• Case Western Reserve University School of Medicine

Hospital

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• Hospital of the University of Pennsylvania

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