Professor, Child Study Center, Yale University School of Medicine
Psychiatry
Dr. Paul J. Lombroso, MD
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Doctor Paul J. Lombroso, MD practices Psychiatry. He researched medicine at Albert Einstein College of Medicine at Jacobi Medical Center. Paul Lombroso is a published doctor and has 99 publications published. The lastest was: 'Sydenham's chorea.'
Publications
- Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition.
- Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP.
- Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders.
- Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption.
- Individualized Assessments in Treatment Research: An Examination of Parent-Nominated Target Problems in the Treatment of Disruptive Behaviors in Youth with Tourette Sy...
- Neuroprotective Role of a Brain-Enriched Tyrosine Phosphatase, STEP, in Focal Cerebral Ischemia.
- Substrate-Based Fragment Identification for the Development of Selective, Nonpeptidic Inhibitors of Striatal-Enriched Protein Tyrosine Phosphatase.
- Striatal-Enriched Protein Tyrosine Phosphatase-STEPs Toward Understanding Chronic Stress-Induced Activation of Corticotrophin Releasing Factor Neurons in the Rat Bed N...
- The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity.
- A Common STEP in the Synaptic Pathology of Diverse Neuropsychiatric Disorders.
- Involvement of PTPN5, the gene encoding the striatal-enriched protein tyrosine phosphatase, in schizophrenia and cognition.
- The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications.
- Therapeutic Implications for Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Neuropsychiatric Disorders.
- Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation.
- Reduced Levels of the Tyrosine Phosphatase STEP Block Beta Amyloid-mediated GluA1/GluA2 Receptor Internalization.
- Transport of animals between rooms: A little-noted aspect of laboratory procedure that may interfere with memory.
- Striatal-Enriched Protein Tyrosine Phosphatase Expression and Activity in Huntington's Disease: A STEP in the Resistance to Excitotoxicity.
- Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase.
- Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory.
- Streptococcal upper respiratory tract infections and exacerbations of tic and obsessive-compulsive symptoms: a prospective longitudinal study.
- Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model.
- The role of STEP in Alzheimer's disease.
- A STEP forward in neural function and degeneration.
- Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61.
- Streptococcal upper respiratory tract infections and psychosocial stress predict future tic and obsessive-compulsive symptom severity in children and adolescents with ...
- Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP.
- Major vault protein is expressed along the nucleus-neurite axis and associates with mRNAs in cortical neurons.
- A substrate trapping mutant form of striatal-enriched protein tyrosine phosphatase prevents amphetamine-induced stereotypies and long-term potentiation in the striatum.
- Knockout of striatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation.
- Learning and memory, part I: brain regions involved in two types of learning and memory.
- The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation.
- Reversing the effects of fragile X syndrome.
- Fragile X syndrome: keys to the molecular genetics of synaptic plasticity.
- Epigenetics: behavioral influences on gene function, Part II: Molecular mechanisms.
- Epigenetics: behavioral influences on gene function, part I. Maternal behavior permanently affects adult behavior in offspring.
- Beta-amyloid modulation of synaptic transmission and plasticity.
- Tourette syndrome and tic disorders: a decade of progress.
- Molecular basis of genetic neuropsychiatric disorders.
- The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala.
- Status epilepticus-induced somatostatinergic hilar interneuron degeneration is regulated by striatal enriched protein tyrosine phosphatase.
- Regulation of NMDA receptor trafficking by amyloid-beta.
- Adaptive, emotional, and family functioning of children with obsessive-compulsive disorder and comorbid attention deficit hyperactivity disorder.
- Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome.
- Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum.
- Atomoxetine and tics in ADHD.
- Prospective longitudinal study of children with tic disorders and/or obsessive-compulsive disorder: relationship of symptom exacerbations to newly acquired streptococc...
- Genetics of childhood disorders: LIII. Learning and memory, part 6: induction of long-term potentiation.
- Genetics of childhood disorders: LI. Learning and memory, Part 4: Human cognitive disorders and the ras/ERK/CREB pathway.
- Development of the Yale Children's Global Stress Index (YCGSI) and its application in children and adolescents ith Tourette's syndrome and obsessive-compulsive disorder.
- Genetics of childhood disorders: XLVIII. Learning and memory, Part 1: Fragile X syndrome update.
- Genetics of childhood disorders: XLVII. Autism, part 6: duplication and inherited susceptibility of chromosome 15q11-q13 genes in autism.
- NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling.
- Disruptive behavior in children with Tourette's syndrome: association with ADHD comorbidity, tic severity, and functional impairment.
- Genetics of childhood disorders: XLVI. Autism, part 5: genetics of autism.
- Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling.
- Assessment of symptom exacerbations in a longitudinal study of children with Tourette's syndrome or obsessive-compulsive disorder.
- Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420.
- An animal model of Tourette's syndrome.
- Genetics of childhood disorders: XXXVII. News flash: a gene for expressive language.
- Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation.
- Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades.
- Learning and memory, part II: molecular mechanisms of synaptic plasticity.
- Severe psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome.
- STEP regulation of seizure thresholds in the hippocampus.
- The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition.
- Taking STEPs forward to understand fragile X syndrome.
- Protein phosphatases and Alzheimer''s disease.
- Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder.
- Translation of striatal-enriched protein tyrosine phosphatase (STEP) after beta1-adrenergic receptor stimulation.
- Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia.
- Identification of pyruvate kinase as an antigen associated with Tourette syndrome.
- Synaptic plasticity: one STEP at a time.
- Microinfusion of antineuronal antibodies into rodent striatum: failure to differentiate between elevated and low titers.
- Schizophrenia in adolescent twins: a case study.
- Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location.
- [Learning and memory].
- Emergence of self-destructive phenomena in children and adolescents during fluoxetine treatment.
- Sydenham's chorea.
- Preliminary findings of antistreptococcal antibody titers and basal ganglia volumes in tic, obsessive-compulsive, and attention deficit/hyperactivity disorders.
- A putative poststreptococcal case of OCD with chronic tic disorder, not otherwise specified.
- Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette's syndrome, Sydenham's chorea, and autoimmune disorders.
- Genetics of childhood disorders: XXX. Autoimmune disorders, part 3: myasthenia gravis and Rasmussen's encephalitis.
- Group A streptococcal infections and their potential role in neuropsychiatric disease.
- Genetics of childhood disorders: XXVIII. Autoimmunity, part I.
- Thermal sensitivity in Tourette syndrome: preliminary report.
- Genetics of central nervous system developmental disorders.
- Genetics of childhood disorders: XXV. Velocardiofacial syndrome.
- The psychiatric symptoms of rheumatic fever.
- The genetics of childhood psychiatric disorders: a decade of progress.
- The Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase STEP via a PKA-dependent pathway.
- Genetics of childhood disorders: XVI. Angelman syndrome: a failure to process.
- Genetics of childhood disorders: XIV. A gene for Rett syndrome: news flash.
- Transient compartmental expression of a family of protein tyrosine phosphatases in the developing striatum.
- Protein tyrosine phosphatases in the nervous system.
- A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures.
- Tourette's syndrome: a multigenerational, neuropsychiatric disorder.
- Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase.
- A neuronal protein tyrosine phosphatase induced by nerve growth factor.
Schools
Albert Einstein College of Medicine of Yeshiva University
Montefiore Med Center
Bronx Municipal Hospital Center
Beth Israel
Doctors Specialties
- Pediatric Psychiatry
- Psychiatry
Accepted Insurances
Education
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Albert Einstein College of Medicine at Jacobi Medical Center -
Albert Einstein - Montefiore Medical Center -
Albert Einstein College of Medicine of Yeshiva University
Hospital
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Yale-New Haven Hospital
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