Professor, Medicine, UCSD School of Medicine
Hematology
Dr. Sanford J. Shattil, MD
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Sanford Shattil is an expert in the field of Hematology. He researched medicine at University of Illinois College of Medicine. He over the years received 4 awards: "CMS Meaningful Use Stage 1 Certification", "Member", "Elected Member" and "Super Doctor". Sanford Shattil is a published doctor and has 100 publications published. The lastest was: 'Membrane microviscosity and human platelet function.' Sanford Shattil is registered with Medicare.
Publications
- Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor.
- The classical lancefield antigen of group a streptococcus is a virulence determinant with implications for vaccine design.
- Carboxy-terminal -COOH of Integrin β1 Is Necessary for β1 Association with the Kindlin-2 Adapter Protein.
- ADAP interactions with talin and kindlin promote Platelet integrin αIIbβ3 activation and stable fibrinogen binding.
- The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3.
- The Primacy of β1 Integrin Activation in the Metastatic Cascade.
- Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3.
- Role for ADAP in shear flow-induced Platelet mechanotransduction.
- An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression.
- Antithrombotic effects of targeting alphaIIbbeta3 signaling in Platelets.
- RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences.
- Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in Platelets.
- The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.
- Differences in regulation of Drosophila and vertebrate integrin affinity by talin.
- Mechanisms and consequences of agonist-induced talin recruitment to Platelet integrin alphaIIbbeta3.
- Roles of focal adhesion kinase (FAK) in megakaryopoiesis and Platelet function: studies using a megakaryocyte lineage specific FAK knockout.
- The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development.
- The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (Platelet GPIIb-IIIa) activation.
- Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.
- Bloodlines: the importance of mentoring for the future of hematology.
- ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.
- Platelet integrin adhesive functions and signaling.
- Matrix-specific suppression of integrin activation in shear stress signaling.
- Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.
- Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity.
- Integrin regulation.
- PTP-1B is an essential positive regulator of Platelet integrin signaling.
- Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain.
- Letter to authors and readers regarding the new NIH policy on public access.
- Regulation of outside-in signaling in Platelets by integrin-associated protein kinase C beta.
- Integrins: dynamic scaffolds for adhesion and signaling in Platelets.
- Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation.
- Protein-protein interactions in Platelet alphaIIbbeta3 signaling.
- Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells.
- Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors.
- Open access, yes! Open excess, no!
- Src kinase activation by direct interaction with the integrin beta cytoplasmic domain.
- Talin binding to integrin beta tails: a final common step in integrin activation.
- Detection of integrin alpha IIbbeta 3 clustering in living cells.
- A (blood) smear campaign.
- Development and analysis of megakaryocytes from murine embryonic stem cells.
- The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains.
- Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.
- Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton.
- Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
- Lateral clustering of Platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3.
- Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.
- Sex hormones, complement-mediated Platelet damage, and hemostasis.
- Use of monoclonal antibodies for the detection and analysis of activated human Platelets.
- Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling.
- Signaling through Platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways.
- Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand.
- Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in Platelets.
- A mutation in the extracellular cysteine-rich repeat region of the beta3 subunit activates integrins alphaIIbbeta3 and alphaVbeta3.
- Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1.
- Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3.
- RhoA and the function of Platelet integrin alphaIIbbeta3.
- Integrin signaling: the Platelet paradigm.
- Integrin signaling in vascular biology.
- Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann Thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex.
- Regulation of the pp72syk protein tyrosine kinase by Platelet integrin alpha IIb beta 3.
- Effect of Ca2+ on GP IIb-IIIa interactions with integrilin: enhanced GP IIb-IIIa binding and inhibition of Platelet aggregation by reductions in the concentration of i...
- Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology.
- Not just another pretty face: regulation of Platelet function at the cytoplasmic face of integrin alpha IIb beta 3.
- Affinity modulation of Platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail.
- A conserved sequence motif in the integrin beta3 cytoplasmic domain is required for its specific interaction with beta3-endonexin.
- A genetic analysis of integrin function: Glanzmann Thrombasthenia in vitro.
- Integrin signaling: roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK.
- Glanzmann Thrombasthenia due to a two amino acid deletion in the fourth calcium-binding domain of alpha IIb: demonstration of the importance of calcium-binding domains...
- A molecular basis for affinity modulation of Fab ligand binding to integrin alphaIIb beta3.
- The Platelet cytoskeleton stabilizes the interaction between alphaIIbbeta3 and its ligand and induces selective movements of ligand-occupied integrin.
- Breaking the integrin hinge. A defined structural constraint regulates integrin signaling.
- Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myriState acetate and roles in...
- Function and regulation of the beta 3 integrins in hemostasis and vascular biology.
- Tyrosine phosphorylation and cytoskeletal reorganization in Platelets are triggered by interaction of integrin receptors with their immobilized ligands.
- Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of Platelet glycoprotein IIb.
- Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb.
- Early changes in cytosolic calcium and membrane potential induced by Actinobacillus actinomycetemcomitans leukotoxin in susceptible and resistant target cells.
- Protein tyrosine phosphorylation and the adhesive functions of Platelets.
- Effect of Platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex.
- Immunological detection of activated platelets in clinical Disorders.
- GTP-binding proteins and Platelet activation.
- Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the re...
- Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human Platelets.
- Decreased content and surface expression of alpha-granule membrane protein GMP-140 in one of two types of Platelet alpha delta storage pool deficiency.
- Role of Platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of Platelet proteins.
- Platelet-derived microparticles express high affinity receptors for factor VIII.
- Modulation of Platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein I...
- A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3.
- Why is Platelet activation useful for assessing thrombotic risk? What are the advantages and limitations of using flow cytometry to measure Platelet activation?
- Anti-idiotypic antibodies against an antibody to the Platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen.
- Regulation of glycoprotein IIb-IIIa receptor function studied with Platelets permeabilized by the pore-forming complement proteins C5b-9.
- Platelet hypersensitivity induced by cholesterol incorporation.
- Membrane microviscosity and human Platelet function.
- Halofenate: a potent inhibitor of normal and hypersensitive Platelets.
- Soluble fibrin complexes in coronary Disease.
- Increased fluidity of human platelet membranes during complement-mediated Immune platelet injury.
- Factors influencing the lipid composition and fluidity of red cell membranes in vitro: production of red cells possessing more than two cholesterols per phospholipid.
- Relationships between cholesterol supply and luteal mitochondrial steroid synthesis.
Schools
University of Illinois At Chicago College of Medicine
Boston City Hospital
Thorndike Meml Lab
Conditions Treated
- Anemia
- Antiphospholipid Syndrome (APS)
- Coagulation Disorders (incl. Hemophilia)
- Deep Vein Thrombosis (DVT)
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Doctors Specialties
- Hematology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Member
- Elected Member
- Super Doctor
Education
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Boston University Medical Center -
Harvard Affiliated Hospitals -
University of Illinois College of Medicine
Drug Facts
| NPI NUMBER | 1679530844 | |
| NPPES Provider LastName | SHATTIL | |
| NPPES Provider FirstName | SANFORD | |
| NPPES Provider ZIPCode | 921039000 | |
| NPPES Provider State | CA | |
| Specialty Description | Hematology | |
| Total Claim Count | 27.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1679530844 |
| Last Name Of The Provider | SHATTIL |
| First Name Of The Provider | SANFORD |
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