Associate Professor, Psychiatry, University Massachusetts Medical School
Psychiatry
Dr. Schahram Akbarian, MD
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Schahram Akbarian works in the field of Psychiatry. Schahram Akbarian, MD is a published doctor. He has 93 publications published. The most current publication "Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients."
Publications
- Pharmacological modulation of astrocytes and the role of cell type-specific histone modifications for the treatment of mood disorders.
- Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse.
- Conserved Higher-Order Chromatin Regulates NMDA Receptor Gene Expression and Cognition.
- Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains.
- Prenatal protein malnutrition decreases KCNJ3 and 2DG activity in rat prefrontal cortex.
- A role for noncoding variation in schizophrenia.
- Analytical tools and current challenges in the modern era of neuroepigenomics.
- Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia.
- Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia.
- Regulation of histone H3K4 methylation in brain development and disease.
- A Unique Set of Centrosome Proteins Requires Pericentrin for Spindle-Pole Localization and Spindle Orientation.
- MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis.
- Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction.
- Prefrontal cortical dysfunction after overexpression of histone deacetylase 1.
- Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology.
- The Genome in Three Dimensions: A New Frontier in Human Brain Research.
- Chromatin-bound RNA and the neurobiology of psychiatric disease.
- Conserved Chromosome 2q31 Conformations Are Associated with Transcriptional Regulation of GAD1 GABA Synthesis Enzyme and Altered in Prefrontal Cortex of Subjects with ...
- Coordinated Cell Type-Specific Epigenetic Remodeling in Prefrontal Cortex Begins before Birth and Continues into Early Adulthood.
- Epigenetics in the human brain.
- Human-specific histone methylation signatures at transcription start sites in prefrontal neurons.
- Epigenetic mechanisms in neurological disease.
- Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome.
- The Polycomb Group Protein L3mbtl2 Assembles an Atypical PRC1-Family Complex that Is Essential in Pluripotent Stem Cells and Early Development.
- The histone deacetylase inhibitor, sodium butyrate, alleviates cognitive deficits in pre-motor stage PD.
- Gender-Specific Reduction of Estrogen-Sensitive Small RNA, miR-30b, in Subjects With Schizophrenia.
- Deciphering H3K4me3 broad domains associated with gene-regulatory networks and conserved epigenomic landscapes in the human brain.
- miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement.
- The future of neuroepigenetics in the human brain.
- Advancing drug discovery for schizophrenia.
- Balancing histone methylation activities in psychiatric disorders.
- Epigenetics of schizophrenia.
- The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism.
- Keep the 'phospho' on MAPK, be happy.
- Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice.
- White matter neuron alterations in schizophrenia and related disorders.
- RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder.
- Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.
- Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B.
- A simple method for improving the specificity of anti-methyl histone antibodies.
- Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex.
- rAAV9--a human-derived adeno-associated virus vector for efficient transgene expression in mouse cingulate cortex.
- The molecular pathology of schizophrenia--focus on histone and DNA modifications.
- Cocaine-induced metabolic activation in cortico-limbic circuitry is increased after exposure to the histone deacetylase inhibitor, sodium butyrate.
- Cingulate white matter neurons in schizophrenia and bipolar disorder.
- Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia.
- Neuronal nuclei isolation from human postmortem brain tissue.
- A chromatin assay for human brain tissue.
- Restoring GABAergic signaling and neuronal synchrony in schizophrenia.
- Epigenetics in the nervous system.
- Approaching the molecular pathology of suicide.
- Epigenetic regulation in human brain-focus on histone lysine methylation.
- A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex.
- Isolation of neuronal chromatin from brain tissue.
- DNA methylation changes in schizophrenia and bipolar disorder.
- Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modula...
- Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters.
- DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons.
- GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia.
- The molecular pathology of Rett syndrome: synopsis and update.
- Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse.
- Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders.
- NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis.
- Chromatin immunoprecipitation in postmortem brain.
- Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.
- Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia.
- Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in ...
- Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling.
- Clinical experts on Rett disorder.
- The neurobiology of Rett syndrome.
- Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain.
- Diseases of the mind and brain: Rett's syndrome, part II.
- Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.
- Diseases of the mind and brain: Rett's syndrome.
- Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.
- Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals.
- Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex.
- Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal.
- Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice.
- Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients.
- Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer''s disease, Huntington''s disease and schizophrenia.
- Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics.
- GABAA receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controls.
- Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
- Corticofugal projections to the vestibular nuclei in squirrel monkeys: further evidence of multiple cortical vestibular fields.
- Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development.
- Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development.
- Corticofugal connections between the cerebral cortex and brainstem vestibular nuclei in the macaque monkey.
- Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain.
- Responses of single neurons in the parietoinsular vestibular cortex of primates.
- Thalamic connections of the vestibular cortical fields in the squirrel monkey (Saimiri sciureus).
- Cortico-cortical connections and cytoarchitectonics of the primate vestibular cortex: a study in squirrel monkeys (Saimiri sciureus).
Schools
Freie Universitaet Berlin Medizinische Fachbereich
Beth Israel Med Center Ny
Massachusetts General Hospital
Doctors Specialties
- Psychiatry
Accepted Insurances
Education
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Massachusetts General Hospital -
Freie University Berlin Faculty of Medicine
Hospital
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Mount Sinai Hospital
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