Professor, Internal Medicine, University of Iowa College of Medicine
Hematology
Dr. Steven R. Lentz, MD
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Steven Lentz is an expert in the field of Hematology. He researched medicine at Washington University School of Medicine in St. Louis. He received 2 awards: "CMS Meaningful Use Stage 1 Certification" and "Elected Member". Steven Lentz is a published MD as well. He has 101 publications published. The latest was: Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice. Steven Lentz accepts Medicare.
Publications
- Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States.
- Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity.
- Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll-Like Receptor 4.
- Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis.
- Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation.
- Endothelial PPAR-γ Protects Against Vascular Thrombosis by Downregulating P-Selectin Expression.
- Cellular fibronectin containing extra domain A promotes arterial Thrombosis in mice through platelet toll-like receptor 4.
- AGXT2: a promiscuous aminotransferase.
- Recombinant factor VIIa analogue in management of Hemophilia with inhibitors: results from a multicenter, randomized, controlled trial of vatreptacog alfa.
- Mechanisms of Thrombosis in obesity.
- Results from a large multinational clinical trial (guardian™1) using prophylactic treatment with turoctocog alfa in adolescent and adult patients with severe haemophil...
- Dominant Negative PPAR? Promotes Atherosclerosis, Vascular Dysfunction and Hypertension Through Distinct Effects in Endothelium and Vascular Muscle.
- Hydrogen Peroxide Promotes Aging-Related Platelet Hyperactivation and Thrombosis.
- ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice.
- ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice.
- Alternatively-spliced extra domain a of fibronectin promotes acute inflammation and brain injury after cerebral ischemia in mice.
- Critical VWF A1 Domain Residues Influence Type VI Collagen Binding.
- Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia.
- ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice.
- Human Thrombomodulin Knock-In Mice Reveal Differential Effects of Human Thrombomodulin on Thrombosis and Atherosclerosis.
- The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocys...
- Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse.
- Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.
- Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production.
- Countervailing effects on atherogenesis and plaque stability: a paradoxical benefit of hypercoagulability?
- Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site.
- Role of hydrogen peroxide and the impact of glutathione peroxidase-1 in regulation of cerebral vascular tone.
- Murine models of hyperhomocysteinemia and their vascular phenotypes.
- Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
- The homocysteine paradox.
- Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction.
- Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and Thrombosis.
- Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation.
- Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia.
- Role of redox reactions in the vascular phenotype of hyperhomocysteinemic animals.
- Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels.
- Cerebral vascular dysfunction during hypercholesterolemia.
- Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.
- Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice.
- Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid...
- Hyperhomocysteinemia increases arterial permeability and stiffness in mice.
- Enhanced susceptibility to arterial Thrombosis in a murine model of hyperhomocysteinemia.
- Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia.
- ApoA-I: a missing link between homocysteine and lipid metabolism?
- Role of FcRgamma and factor XIIIA in coated Platelet formation.
- Cerebral vascular dysfunction in methionine synthase-deficient mice.
- Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia.
- Mechanisms of the atherogenic effects of elevated homocysteine in experimental models.
- Another lesson from the factor V Leiden mouse: thrombin generation drives arterial Disease.
- Homocysteine: is it a clinically important cardiovascular risk factor?
- Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice.
- Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice.
- Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia.
- Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.
- Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction.
- Platelet factor 4 enhances generation of activated protein C in vitro and in vivo.
- Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive Immune compartments.
- Thrombosis of Vein grafts: wall tension restrains thrombomodulin expression.
- Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction.
- Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice.
- Prothrombotic States that Predispose to Stroke.
- Role of the adapter protein SLP-76 in GPVI-dependent Platelet procoagulant responses to collagen.
- Effect of hyperhomocysteinemia on protein C activation and activity.
- Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys.
- Factor V Leiden: a genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor-cleaving protease activity.
- Case report: paroxysmal cold hemoglobinuria presenting during pregnancy.
- Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia.
- Nuclear membrane-associated cyclophilins of potential importance in cyclosporine immunosuppression.
- Structure-function relationships of the thrombin-thrombomodulin interaction.
- Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion.
- Remission after 13-cis retinoic acid in thrombotic Thrombocytopenic purpura.
- Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues.
- Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin.
- Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine.
- Severe acquired functional protein S deficiency and skin necrosis in a patient with ANCA-associated vasculitis.
- Proteolytic processing of human preproapolipoprotein A-I. A proposed defect in the conversion of pro A-I to A-I in Tangier's Disease.
- Endothelial protein C activation in meningococcal sepsis.
- Regulation of thrombomodulin by tumor necrosis factor-alpha: comparison of transcriptional and posttranscriptional mechanisms.
- [Mutation in factor II and factor V gene in patients with peripheral arterial occlusive Disease].
- Homocysteine and vascular dysfunction.
- Platelet antibody testing in idiopathic Thrombocytopenic purpura.
- Does homocysteine promote atherosclerosis?
- Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity.
- Ligand specificity of human thrombomodulin. Equilibrium binding of human thrombin, meizothrombin, and factor Xa to recombinant thrombomodulin.
- Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum.
- The benefits of excess EPCR.
- Homocysteine and its disulfide derivatives: a suggested consensus terminology.
- Mechanisms of Thrombosis in hyperhomocysteinemia.
- Functional interactions between the thrombin receptor and the T-cell antigen receptor in human T-cell lines.
- Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans.
- Atherosclerotic vascular Disease: will folate or gene therapy be useful?
- Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways.
- Mechanisms of homocysteine-induced atheroThrombosis.
- Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin.
- Cellular localization of thrombomodulin in human epithelium and squamous malignancies.
- Expression of thrombomodulin and consequences of thrombomodulin deficiency during healing of cutaneous wounds.
- Thrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation.
- Interference in protein C activation assays from endogenous serpins in mammalian host cells.
- Fetal hemorrhage and Platelet dysfunction in SLP-76-deficient mice.
- Keratinocyte-specific expression of human thrombomodulin in transgenic mice: effects on epidermal differentiation and cutaneous wound healing.
Schools
Washington Center School of Medicine
Barnes Jewish Hospital
Washington University
Conditions Treated
- Anemia
- Antiphospholipid Syndrome (APS)
- Chronic Myeloid Leukemia (CML)
- Coagulation Disorders (incl. Hemophilia)
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Doctors Specialties
- Hematology
Accepted Insurances
- Choice Plus POS II
- American Republic
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- First Health (Coventry Health Care) PPO
- Golden Rule
- Choice Care PPO
- Medicare MCR
- Principal Life
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
- Alliance Select
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
Education
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Washington University - Barnes-Jewish Hospital -
Washington University School of Medicine in St. Louis
Drug Facts
| NPI NUMBER | 1316934318 | |
| NPPES Provider LastName | LENTZ | |
| NPPES Provider FirstName | STEVEN | |
| NPPES Provider ZIPCode | 522421009 | |
| NPPES Provider State | IA | |
| Specialty Description | Hematology | |
| Total Claim Count | 135.0 | |
| Distinct Opioid Count | 3.0 | |
| Opioid Claim Count | 44.0 | |
| Percent Opioid Claims | 32.59 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1316934318 |
| Last Name Of The Provider | LENTZ |
| First Name Of The Provider | STEVEN |
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