Physician
Allergy & Immunology
Dr. Thomas B. Nutman, MD
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Dr. Thomas B. Nutman works in the field of Allergy & Immunology. He researched medicine at NYU School of Medicine. He over the years received 1 awards: "Elected Member". Dr. Thomas B. Nutman is also published. He has 101 publications published. The lastest publication: "Modulation of pro- and anti-inflammatory cytokines in active and latent tuberculosis by coexistent Strongyloides stercoralis infection.'
Publications
- Modulation of CD4+ and CD8+ T cell function in filarial infections by IL-19 and IL-24.
- Modulation of pro- and anti-inflammatory cytokines in active and latent tuberculosis by coexistent Strongyloides stercoralis infection.
- Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis.
- Parasite Antigen-Specific Regulation of Th1, Th2, and Th17 Responses in Strongyloides stercoralis Infection.
- Treatment of W. bancrofti (Wb) in HIV/Wb Coinfections in South India.
- Filarial Infection Modulates the Immune Response to Mycobacterium tuberculosis through Expansion of CD4+ IL-4 Memory T Cells.
- Analysis of nematode motion using an improved light-scatter based system.
- Eosinophil-associated processes underlie differences in clinical presentation of loiasis between temporary residents and those indigenous to Loa-endemic areas.
- Helminth-induced immune regulation: implications for immune responses to tuberculosis.
- Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden.
- Brugia malayi infective larvae fail to activate Langerhans cells and dermal dendritic cells in human skin.
- Type 2 diabetes mellitus is associated with altered CD8(+) T and NK cell function in pulmonary tuberculosis.
- Coincident helminth infection modulates systemic inflammation and immune activation in active pulmonary tuberculosis.
- Helminth Infection Alters IgE Responses to Allergens Structurally Related to Parasite Proteins.
- Human monocyte subsets at homeostasis and their perturbation in numbers and function in filarial infection.
- Co-infection of Long-Term Carriers of Plasmodium falciparum with Schistosoma haematobium Enhances Protection from Febrile Malaria: A Prospective Cohort Study in Mali.
- Repurposed Automated Handheld Counter as a Point-of-Care Tool to Identify Individuals 'At Risk' of Serious Post-Ivermectin Encephalopathy.
- Helminth Infections Coincident with Active Pulmonary Tuberculosis Inhibit Mono- and Multifunctional CD4+ and CD8+ T Cell Responses in a Process Dependent on IL-10.
- IL-10 and TGFβ independent regulation of CD8+ T cells expressing Type 1 and Type 2 cytokines in human lymphatic filariasis.
- Altered CD8(+) T cell frequency and function in tuberculous lymphadenitis.
- Development of a suspension array assay in multiplex for the simultaneous measurement of serum levels of four eosinophil granule proteins.
- Diminished systemic and antigen-specific Type 1, Type 17 and other pro-inflammatory cytokines in diabetic and pre-diabetic individuals with latent tuberculosis.
- Testicular Swelling Due to Lymphatic Filariasis after Brief Travel to Haiti.
- IL-1- and IL-23-mediated expansion of filarial - antigen specific Th17 and Th22 cells in filarial lymphedema.
- Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-saharan Africa.
- Loop-Mediated Isothermal Amplification (LAMP) for the Rapid and Semi-Quantitative Detection of Loa loa Infection.
- Expansion of Parasite-Specific CD4+ and CD8+ T Cells Expressing IL-10 Superfamily Cytokine Members and Their Regulation in Human Lymphatic Filariasis.
- Highly heterogeneous, activated and short-lived regulatory T cells during chronic filarial infection.
- Comparison of Three Immunoassays for the Detection of Antibodies to Strongyloides stercoralis.
- Diagnostic accuracy of five serologic tests for Strongyloides stercoralis infection.
- Parasite-Antigen Driven Expansion of IL-5(-) and IL-5(+) Th2 Human Subpopulations in Lymphatic Filariasis and Their Differential Dependence on IL-10 and TGFβ.
- IL-4-, TGF-β-, and IL-1-Dependent Expansion of Parasite Antigen-Specific Th9 Cells Is Associated with Clinical Pathology in Human Lymphatic Filariasis.
- Insights into the pathogenesis of disease in human lymphatic filariasis.
- Rapid Wuchereria bancrofti-Specific Antigen Wb123-Based IgG4 Immunoassays as Tools for Surveillance following Mass Drug Administration Programs on Lymphatic Filariasis.
- Expansion of Pathogen - Specific Th1 and Th17 cells in Pulmonary Tuberculosis with Coincident Type 2 Diabetes Mellitus.
- Modulation of Mycobacterial-Specific Th1 and Th17 Cells in Latent Tuberculosis by Coincident Hookworm Infection.
- Expansion of pathogen-specific mono- and multifunctional Th1 and th17 cells in multi-focal tuberculous lymphadenitis.
- A Novel, Multi-Parallel, Real-Time Polymerase Chain Reaction Approach for Eight Gastrointestinal Parasites Provides Improved Diagnostic Capabilities to Resource-Limite...
- Circulating biomarkers of pulmonary and extra-pulmonary tuberculosis in children.
- Genomics of Loa loa, a Wolbachia-free filarial parasite of humans.
- Quiescent Innate Response to Infective Filariae by Human Langerhans Cells Suggests a Strategy of Immune Evasion.
- Identification of Wb123 as an Early and Specific Marker of Wuchereria bancrofti Infection.
- Antibody to the Filarial Antigen Wb123 Reflects Reduced Transmission and Decreased Exposure in Children Born following Single Mass Drug Administration (MDA).
- Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis.
- Prevalence of Strongyloides stercoralis in an urban US AIDS cohort.
- Structural Differences between Human Proteins and Aero- and Microbial Allergens Define Allergenicity.
- Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization.
- Impact of filarial infections on coincident intracellular pathogens: Mycobacterium tuberculosis and Plasmodium falciparum.
- Peripheral blood stem cell transplant-related Plasmodium falciparum infection in a patient with sickle cell disease.
- Interferon regulatory factor modulation underlies the bystander suppression of malaria antigen-driven IL-12 and IFN-? in filaria-malaria co-infection.
- Filarial and Wolbachia Genomics.
- Suppressed Type 1, Type 2 and Type 17 cytokine responses in Active Tuberculosis in Children.
- Filarial Lymphatic Pathology Reflects Augmented TLR-mediated, MAPK-mediated Pro-inflammatory Cytokine Production.
- Immunization with the recombinant antigen Ss-IR induces protective immunity to infection with Strongyloides stercoralis in mice.
- Rapid Molecular Assays for Specific Detection and Quantitation of Loa loa Microfilaremia.
- Functional and Phenotypic Characteristics of Alternative Activation Induced in Human Monocytes by IL-4 or the Parasitic Nematode Brugia malayi.
- Heightened measures of immune complex and complement function and immune complex-mediated granulocyte activation in human lymphatic filariasis.
- Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia.
- Filarial infection suppresses malaria-specific multifunctional Th1 and th17 responses in malaria and filarial coinfections.
- Structural and immunologic cross-reactivity among filarial and mite tropomyosin: implications for the hygiene hypothesis.
- Microarray-Based Analysis of Differential Gene Expression between Infective and Noninfective Larvae of Strongyloides stercoralis.
- Toward molecular parasitologic diagnosis: enhanced diagnostic sensitivity for filarial infections in mobile populations.
- Altered T cell memory and effector cell development in chronic lymphatic filarial infection that is independent of persistent parasite antigen.
- Our history with parasites.
- Decreased prevalence of lymphatic filariasis among subjects with type-1 diabetes.
- Use of high-dose, twice-yearly albendazole and ivermectin to suppress Wuchereria bancrofti microfilarial levels.
- Expanded numbers of circulating myeloid dendritic cells in patent human filarial infection reflect lower CCR1 expression.
- Improved diagnosis of Strongyloides stercoralis using recombinant antigen-based serologies in a community-wide study in northern Argentina.
- Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections.
- At homeostasis filarial infections have expanded adaptive T regulatory but not classical Th2 cells.
- Decreased prevalence of lymphatic filariasis among diabetic subjects associated with a diminished pro-inflammatory cytokine response (CURES 83).
- Regulatory T cells modulate Th17 responses in patients with positive tuberculin skin test results.
- Lymphatics in human lymphatic filariasis: in vitro models of parasite-induced lymphatic remodeling.
- Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.
- Lymphangiogenesis and lymphatic remodeling induced by filarial parasites: implications for pathogenesis.
- Heritable factors play a major role in determining host responses to Wuchereria bancrofti infection in an isolated South Pacific island population.
- A randomized trial of doxycycline for Mansonella perstans infection.
- Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria/malaria-coinfected population.
- Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1.
- Evidence for in utero sensitization to Ascaris lumbricoides in newborns of mothers with ascariasis.
- Alternatively activated and immunoregulatory monocytes in human filarial infections.
- Community based parasitic screening and treatment of Sudanese refugees: application and assessment of Centers for Disease Control guidelines.
- A four-antigen mixture for rapid assessment of Onchocerca volvulus infection.
- Attenuation of toll-like receptor expression and function in latent tuberculosis by coexistent filarial infection with restoration following antifilarial chemotherapy.
- Activation and regulation of toll-like receptors (TLRs) by helminth parasites.
- Brugia malayi excreted/secreted proteins at the host/parasite interface: stage- and gender-specific proteomic profiling.
- Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cells.
- Induction of TRAIL- and TNF-alpha-dependent apoptosis in human monocyte-derived dendritic cells by microfilariae of Brugia malayi.
- Filarial/human immunodeficiency virus coinfection in urban southern India.
- Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites.
- A luciferase immunoprecipitation systems assay enhances the sensitivity and specificity of diagnosis of Strongyloides stercoralis infection.
- Rapid, novel, specific, high-throughput assay for diagnosis of Loa loa infection.
- A 41-year-old woman from Cameroon with infertility.
- Ascaris lumbricoides-induced interleukin-10 is not associated with atopy in schoolchildren in a rural area of the tropics.
- Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste.
- CD4(+) (and not CD25+) T cells are the predominant interleukin-10-producing cells in the circulation of filaria-infected patients.
- Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing.
- Draft genome of the filarial nematode parasite Brugia malayi.
- KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities.
- Filarial parasites induce NK cell activation, type 1 and type 2 cytokine secretion, and subsequent apoptotic cell death.
Schools
University of Cincinnati Main Campus
Doctors Specialties
- Internal Medicine
- Allergy
- Immunology
Accepted Insurances
Awards
- Elected Member
Education
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National Institutes of Health Clinical Center -
NYU School of Medicine -
University of Cincinnati College of Medicine
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