Professor of Pediatrics, Ohio State University
Neurology
Dr. Zarife Sahenk, MD
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Doctor Zarife Sahenk, MD works in the field of Neurology. She has 1 awards "Regional Top Doctor". Zarife Sahenk has written publications. She has 95 publications published with PubMed. The lastest publication is: 'Comparative intravenous toxicity of cisplatin solution and cisplatin encapsulated in long-circulating, pegylated liposomes in cynomolgus monkeys.'
Publications
- Defective membrane fusion and repair in Anoctamin5 -deficient Muscular dystrophy.
- A slowly progressive form of limb-girdle Muscular dystrophy type 2C associated with founder mutation in the SGCG gene in Puerto Rican Hispanics.
- AAV.Dysferlin Overlap Vectors Restore Function in Dysferlinopathy Animal Models.
- A Phase I/IIa Follistatin Gene Therapy Trial for Becker Muscular Dystrophy.
- VIP Expressing Dendritic Cells Protect Against Spontaneous Autoimmune Peripheral Polyneuropathy.
- Pathogenesis of autosomal dominant hereditary spastic paraplegia (SPG6) revealed by a rat model.
- AAV1.NT-3 gene therapy for Charcot-Marie-Tooth Neuropathy.
- Vascular delivery of rAAVrh74.MCK.GALGT2 to the gastrocnemius muscle of the rhesus macaque stimulates the expression of dystrophin and laminin α2 surrogates.
- Plasmapheresis Eliminates the Negative Impact of AAV Antibodies on Microdystrophin Gene Expression Following Vascular Delivery.
- Eteplirsen for the treatment of duchenne Muscular dystrophy.
- Molecular and clinical characterization of the myopathic form of mitochondrial DNA depletion Syndrome caused by mutations in the thymidine kinase (TK2) gene.
- Impaired regeneration in LGMD2A supported by increased PAX7-positive satellite cell content and muscle-specific microrna dysregulation.
- Update on the treatment of duchenne Muscular dystrophy.
- Camptocormia as a late presentation in a manifesting carrier of duchenne Muscular dystrophy.
- Gene Therapy for Muscular Dystrophy: Lessons Learned and Path Forward.
- Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice.
- Autonomic impairment in painful Neuropathy.
- Superficial peroneal nerve/peroneus brevis muscle biopsy in vasculitic Neuropathy.
- Intracellular processing and Toxicity of the truncated androgen receptor: nuclear congophilia-associated cell death.
- Novel compound heterozygous laminina2-chain gene (LAMA2) mutations in congenital Muscular dystrophy. Mutations in brief no. 159. Online.
- Alterations in nodes of Ranvier and Schmidt-Lanterman incisures in Charcot-Marie-Tooth neuropathies.
- Abnormal Schwann cell-axon interactions in CMT neuropathies. The effects of mutant Schwann cells on the axonal cytoskeleton and regeneration-associated myelination.
- Painful sensory Neuropathy: prospective evaluation using skin biopsy.
- Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival.
- Comparative intravenous Toxicity of cisplatin solution and cisplatin encapsulated in long-circulating, pegylated liposomes in cynomolgus monkeys.
- Effects of PMP22 duplication and deletions on the axonal cytoskeleton.
- A novel PMP22 point mutation causing HNPP phenotype: studies on Nerve xenografts.
- Fate of Schwann cells in CMT1A and HNPP: evidence for apoptosis.
- Abnormalities in the axonal cytoskeleton induced by a connexin32 mutation in Nerve xenografts.
- Gene delivery to spinal motor neurons.
- Polyneuropathy complicating bone marrow and solid organ transplantation.
- Immunosuppressive treatment of motor neuron Syndromes. Attempts to distinguish a treatable disorder.
- Inclusion body myositis: treatment with intravenous immunoglobulin.
- Taxol Neuropathy. Electrodiagnostic and sural nerve biopsy findings.
- CNTF potentiates Peripheral nerve regeneration.
- The childhood muscular dystrophies: Diseases sharing a common pathogenesis of membrane instability.
- Myoblast transfer in the treatment of Duchenne's Muscular dystrophy.
- Inclusion body myositis: explanation for poor response to immunosuppressive therapy.
- Fatal infantile mitochondrial myopathy and renal dysfunction due to cytochrome-c-oxidase deficiency.
- The experimental production of Renaut bodies.
- Studies on the morphologic alterations of axonal membraneous organelles in neurofilamentous neuropathies.
- Changes in sciatic Nerve cathepsin D after ligation or exposure to neurotoxins.
- The spontaneously Diabetic BB Wistar rat. Morphologic and physiologic studies of peripheral nerve.
- Acrylamide and 2,5-hexanedione neuropathies: abnormal bidirectional transport rate in distal axons.
- Axoplasmic transport in zinc pyridinethione neuropathy: evidence for an Abnormality in distal turn-around.
- Plasma exchange and prednisone in acute Inflammatory polyradiculoneuropathy: a controlled randomized trial.
- Plasma exchange and prednisone in Guillain-Barré Syndrome: a controlled randomized trial.
- Characterization of a murine model for human bismuth encephalopathy.
- Studies on the pathogenesis of vincristine-induced Neuropathy.
- Axonal tubulin and microtubules: morphologic evidence for stable regions on axonal microtubules.
- Polyneuropathy and IgM monoclonal gammopathy: studies on the pathogenetic role of anti-myelin-associated glycoprotein antibody.
- Inhibition of proteolysis blocks anterograde-retrograde conversion of axonally transported vesicles.
- Carbon disulfide axonopathy. Another experimental model characterized by acceleration of neurofilament transport and distinct changes of axonal size.
- Recurrent respiratory insufficiency and depressed ventilatory drive complicating mitochondrial myopathies.
- Distal terminal axonopathy produced by 2,4-dithiobiuret: effects of long-term inToxication in rats.
- The Bruns-Garland Syndrome (diabetic amyotrophy). Revisited 100 years later.
- Weak-base amines inhibit the anterograde-to-retrograde conversion of axonally transported vesicles in Nerve terminals.
- Immunocytochemical evidence for the retrograde transport of intraaxonal cathepsin D: possible relevance to the dying-Back process.
- Amyloid filaments in inclusion body myositis. Novel findings provide insight into nature of filaments.
- Alterations in slow transport kinetics induced by estramustine phosphate, an agent binding to microtubule-associated proteins.
- Inclusion body myositis.
- Significance of creatine phosphokinase isoenzymes in Duchenne Dystrophy.
- Peripheral nerve changes induced by local application of bee venom.
- PolyradiculoNeuropathy accompanying procainamide-induced lupus erythematosus: evidence for drug-induced enhanced sensitization to peripheral nerve myelin.
- Relevance of genetic animal models of Muscular dystrophy to human Muscular dystrophies.
- Ultrastructural study of zinc pyridinethione-induced peripheral Neuropathy.
- Polyneuropathy from inhalation of N2O cartridges through a whipped-cream dispenser.
- Analysis of fast axoplasmic transport in Nerve ligation and adriamycin-induced neuronal perikaryon lesions.
- Alterations of fast axoplasmic transport in experimental methyl n-butyl ketone Neuropathy.
- Nonsystemic vasculitic Neuropathy: insights from a clinical cohort.
- NT-3 promotes Nerve regeneration and sensory improvement in CMT1A mouse models and in patients.
- Pathogenesis of X-linked Charcot-Marie-Tooth Disease: differential effects of two mutations in connexin 32.
- Evidence for impaired axonal regeneration in PMP22 duplication: studies in Nerve xenografts.
- Clinical practice. Painful sensory Neuropathy.
- Knee extensor strength exhibits potential to predict function in sporadic inclusion-body myositis.
- The Muscular dystrophies: distinct pathogenic mechanisms invite novel therapeutic approaches.
- Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle Muscular dystrophy, type 2D.
- Dystrophin immunity in Duchenne's Muscular dystrophy.
- A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA Disease phenotype.
- TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice.
- Novel diagnostic features of dysferlinopathies.
- Direct immunofluoresence in vasculitic Neuropathy: specificity of vascular immune deposits.
- Gentamicin-induced readthrough of stop codons in Duchenne Muscular dystrophy.
- Follistatin gene delivery enhances muscle growth and strength in nonhuman primates.
- Persistent expression of FLAG-tagged micro dystrophin in nonhuman primates following intraMuscular and vascular delivery.
- Limb-girdle Muscular dystrophy type 2D gene therapy restores alpha-sarcoglycan and associated proteins.
- Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice.
- Hypotonia, weakness, and pontocerebellar hypoplasia in siblings.
- Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration.
- Neurotrophin-3 deficient Schwann cells impair Nerve regeneration.
- Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors.
- Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne Muscular dystrophy.
- Neurotrophins and Peripheral neuropathies.
- Dystrophin glycoprotein complex dysfunction: a regulatory link between Muscular dystrophy and cancer cachexia.
Schools
Ankara Universitesi Tip Fakultesi
Hacettepe University Hospital
Ohio State University Hosps
Procedures Preformed
- EMG (Electromyography)
Conditions Treated
- Anterior Horn Background: yellow;'>Disease
- Ataxia
- Carpal Tunnel Background: yellow;'>Background: yellow;'>Background: yellow;'>Background: yellow;'>Syndrome
- Chronic Background: yellow;'>Inflammatory Demyelinating Polyneuritis
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Doctors Specialties
- Neurology
Accepted Insurances
Awards
- Regional Top Doctor
Education
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Ohio State University Hospital
Hospital
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Nationwide Children's Hospital -
Ohio State University Wexner Medical Center
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